carbamazepine vs oxycodone

According to this portal's Publishing Organization, this page was last reviewed in August 2026 against our methodology. Figures and extracts on this site, including tables above 1,000 rows when the corpus is that large, are the publisher's responsibility.

Side-by-side comparison of carbamazepine and oxycodone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.

moderate Known Drug Interaction

Examples: Rifampin, carbamazepine, phenytoin Benzodiazepines and Other Central Nervous System (CNS) Depressants Clinical Impact: Due to additive pharmacologic effect, the concomitant use of benzodiazepines or other CNS depressants, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death [see Warnings and Precautions (5.3)] .

Drug Class
carbamazepine Anticonvulsant
oxycodone Opioid Analgesic
Type
carbamazepine Prescription
oxycodone Prescription
Summary
carbamazepine

Carbamazepine is a medicine used to control seizures and treat nerve pain. It works by reducing abnormal electrical activity in the brain and calming nerve signals.

oxycodone

Oxycodone is a strong pain medicine. It is used to treat severe pain that is not helped by other treatments.

What It Treats
carbamazepine

Carbamazepine is used to treat certain types of seizures, including partial seizures and generalized tonic-clonic seizures. It can also treat mixed seizure patterns. Carbamazepine also treats the pain from trigeminal neuralgia, a nerve disorder that causes intense facial pain. It is also sometimes used for glossopharyngeal neuralgia.

oxycodone

Oxycodone is used to manage severe pain. It is for pain that requires an opioid medicine. You should only use it when other pain treatments are not enough. Talk to your doctor about other options if possible.

How It Works
carbamazepine

Carbamazepine is an anticonvulsant. It works by reducing the spread of seizure activity in the brain. It also stabilizes nerve impulses to reduce pain.

oxycodone

Oxycodone works by changing how your brain and nervous system respond to pain. It attaches to certain receptors in the brain. This helps to block pain signals and reduce pain.

Common Side Effects
carbamazepine
  • Dizziness
  • Drowsiness
  • Unsteadiness
  • Nausea
  • Vomiting
oxycodone
  • Feeling sick to your stomach
  • Constipation
  • Throwing up
  • Headache
  • Itching
FAERS Reports
carbamazepine
  • Seizure 3,609
  • Drug Interaction 3,369
  • Fall 3,044
  • Dizziness 2,862
  • Pyrexia 2,689
oxycodone
  • Drug Dependence 27,480
  • Pain 26,409
  • Death 19,598
  • Overdose 19,081
  • Toxicity To Various Agents 16,253
Serious Warnings
carbamazepine

Carbamazepine can cause severe skin reactions, including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which can be fatal. If you are of Asian descent, you may need a blood test before starting this medicine. Carbamazepine can also cause serious blood problems like aplastic anemia and agranulocytosis. Contact your doctor right away if you develop a fever, sore throat, rash, or unusual bleeding or bruising.

oxycodone

Oxycodone can cause serious, life-threatening risks: * Addiction, abuse, and misuse can lead to overdose and death. Your doctor will check your risk before prescribing and during treatment. * It can cause very slow or stopped breathing, especially when you start taking it or after a dose increase. * If a child accidentally takes even one dose, it can cause a fatal overdose. * Taking it with benzodiazepines (like Xanax) or other depressants (like alcohol) can cause sleepiness, slowed breathing, coma, and death. * Using oxycodone for a long time during pregnancy can cause withdrawal symptoms in the newborn. * Taking oxycodone with certain other medicines can cause dangerous side effects.

Pregnancy
carbamazepine

Carbamazepine may harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if carbamazepine passes into breast milk, so talk to your doctor about breastfeeding.

oxycodone

Using oxycodone for a long time during pregnancy can cause withdrawal symptoms in the baby after birth. Talk to your doctor about the risks if you are pregnant or plan to become pregnant. Oxycodone is not recommended during labor, as it can cause breathing problems in the newborn.

Also Compare, Nearby Drugs

How to Read This carbamazepine vs oxycodone Comparison

carbamazepine is classified in the Anticonvulsant drug class, while oxycodone sits within the Opioid Analgesic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.

Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, carbamazepine has 15,573 submissions while oxycodone has 108,821. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to both of these medications can slow down your brain and body functions. when used together, they can cause dangerously low blood pressure, extreme sleepiness, or breathing problems.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.

A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for carbamazepine or oxycodone.

Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.