Oxycodone and Phenytoin Interaction
Drug interaction information between Oxycodone and Phenytoin.
Oxycodone and Phenytoin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Oxycodone and Phenytoin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs slow down your brain and body, which can cause dangerous sleepiness and very slow breathing.
FDA Label Information
Examples: Rifampin, carbamazepine, phenytoin Benzodiazepines and Other Central Nervous System (CNS) Depressants Clinical Impact: Due to additive pharmacologic effect, the concomitant use of benzodiazepines or other CNS depressants, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death [see Warnings and Precautions (5.3)] .
Oxycodone Also Interacts With
- Carbamazepine moderate
- Rifampin moderate
- Buprenorphine moderate
- Butorphanol moderate
- Nalbuphine moderate
Phenytoin Also Interacts With
- Nirmatrelvir/Ritonavir major
- Posaconazole major
- Ranolazine major
- Voriconazole major
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Oxycodone + Phenytoin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenytoin has 147 labeled pairs on file vs Oxycodone's 28. In the moderate band specifically: Oxycodone has 6 (also Carbamazepine, Rifampin, Buprenorphine, Butorphanol); Phenytoin has 23 (also Apixaban, Aprepitant, Canagliflozin, Carbidopa/Levodopa).
What mechanism field is on file for Oxycodone and Phenytoin?
Both drugs slow down your brain and body, which can cause dangerous sleepiness and very slow breathing.
Phenytoin carries more major-labeled pairs than Oxycodone
SPL source-record counts only. This page's band is moderate · classes on file: Oxycodone (Opioid Analgesic); Phenytoin (Anticonvulsant (Hydantoin)).
Phenytoin has 4 major-labeled pairs vs Oxycodone's 0. This page itself is in the moderate band, not the major band.
0 major · 6 moderate · 22 minor · 28 total
- Other moderate peers for Oxycodone
- Carbamazepine
- Rifampin
- Buprenorphine
- Butorphanol
4 major · 23 moderate · 120 minor · 147 total
- Other moderate peers for Phenytoin
- Apixaban
- Aprepitant
- Canagliflozin
- Carbidopa/Levodopa
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.