Clopidogrel and Apixaban Interaction
Drug interaction information between Clopidogrel and Apixaban.
Clopidogrel and Apixaban have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Clopidogrel and Apixaban. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines prevent blood clots in different ways, and using them together significantly increases your risk of serious bleeding. Clinical trials were even stopped early because this combination caused too much bleeding.
FDA Label Information
APPRAISE-2, a placebo-controlled clinical trial of apixaban in high-risk, post-acute coronary syndrome patients treated with aspirin or the combination of aspirin and clopidogrel, was terminated early due to a higher rate of bleeding with apixaban compared to placebo.
Clopidogrel Also Interacts With
- Omeprazole moderate
- Warfarin moderate
- Esomeprazole moderate
- Rifampin moderate
- Norepinephrine moderate
Apixaban Also Interacts With
- Aspirin moderate
- Warfarin moderate
- Carbamazepine moderate
- Rifampin moderate
- Heparin moderate
Frequently Asked Questions
What SPL severity band is on file for Clopidogrel + Apixaban?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clopidogrel has 19 labeled pairs on file vs Apixaban's 12. In the moderate band specifically: Clopidogrel has 9 (also Omeprazole, Warfarin, Esomeprazole, Rifampin); Apixaban has 9 (also Aspirin, Warfarin, Carbamazepine, Rifampin).
What mechanism field is on file for Clopidogrel and Apixaban?
Both of these medicines prevent blood clots in different ways, and using them together significantly increases your risk of serious bleeding. Clinical trials were even stopped early because this combination caused too much bleeding.
Clopidogrel's labeled portfolio outnumbers Apixaban
SPL source-record counts only. This page's band is moderate · classes on file: Clopidogrel (Antiplatelet Agent); Apixaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)).
0 major · 9 moderate · 10 minor · 19 total
- Other moderate peers for Clopidogrel
- Omeprazole
- Warfarin
- Esomeprazole
- Rifampin
0 major · 9 moderate · 3 minor · 12 total
- Other moderate peers for Apixaban
- Aspirin
- Warfarin
- Carbamazepine
- Rifampin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.