clopidogrel vs omeprazole
Side-by-side comparison of clopidogrel and omeprazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Omeprazole or Esomeprazole Avoid concomitant use of clopidogrel with omeprazole or esomeprazole. In clinical studies, omeprazole was shown to reduce significantly the antiplatelet activity of clopidogrel when given concomitantly or 12 hours apart. A similar reduction in antiplatelet activity was observed with esomeprazole when given concomitantly with clopidogrel.
Recommendation: Avoid taking these two drugs together. Your doctor may suggest a different medicine for your stomach.
Plavix
Prilosec
Clopidogrel is a drug that helps to prevent blood clots. It is used to lower your risk of heart attack and stroke.
Omeprazole (Prilosec) is a medicine that reduces the amount of acid in your stomach. It belongs to a class of drugs called proton pump inhibitors (PPIs).
Clopidogrel is used to prevent heart attack and stroke in adults. It is for people who have had a recent heart attack or stroke. It is also for people with peripheral arterial disease (poor circulation). Clopidogrel can also help people with chest pain or certain heart problems.
This medicine treats frequent heartburn, which is heartburn that occurs 2 or more days a week. It is not meant to give you immediate relief from heartburn. It may take 1 to 4 days for the medicine to fully work.
Clopidogrel keeps blood platelets from sticking together and forming clots. It blocks a substance that causes platelets to clump. This helps blood flow more freely through your body.
Omeprazole works by blocking the production of acid in your stomach. It does this by targeting the cells that make stomach acid. This helps to reduce heartburn symptoms.
- • Bleeding
- • Headache
- Shortness of breath 9,917
- Heart attack 9,461
- Tiredness 8,476
- Bleeding in the stomach or intestines 8,205
- Feeling sick to your stomach 7,878
- Tiredness 19,903
- Feeling sick to your stomach 19,841
- Loose stools 19,625
- Difficulty breathing 16,336
- Headache 14,629
This drug may not work well for people with certain genes. If you have two copies of a certain gene, clopidogrel may not prevent clots as well. Your doctor may consider a different medicine for you.
Children under 18 should ask a doctor before use. Heartburn in children may be a sign of a serious condition.
Tell your doctor if you are pregnant or plan to become pregnant. Clopidogrel may increase bleeding during labor and delivery. Talk to your doctor about the risks and benefits of taking this medicine while pregnant or breastfeeding.
Talk to your doctor if you are pregnant or breastfeeding before taking this medicine. It is important to weigh the benefits and risks with your doctor.
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How to Read This clopidogrel vs omeprazole Comparison
clopidogrel is classified in the Antiplatelet Agent drug class, while omeprazole sits within the Proton Pump Inhibitor (PPI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, clopidogrel has 43,937 submissions while omeprazole has 90,334. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to omeprazole stops clopidogrel from working correctly by preventing it from turning into its active form. this makes the medicine less effective at stopping blood clots.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between clopidogrel and omeprazole - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.