Fluvastatin and Cyclosporine Interaction
Drug interaction information between Fluvastatin and Cyclosporine.
Fluvastatin and Cyclosporine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fluvastatin and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cyclosporine makes it harder for your body to get rid of fluvastatin, leading to higher levels of the cholesterol medicine in your blood.
FDA Label Information
7 DRUG INTERACTIONS Cyclosporine: Combination increases fluvastatin exposure. Caution should be used when prescribing with fluvastatin ( 5.1 , 7.3 , 7.4 ) Glyburide: Monitor blood glucose levels when fluvastatin dose is changed ( 7 ) Phenytoin: Monitor plasma phenytoin levels when fluvastatin treatment is initiated or when the dosage is changed ( 7 ) Warfarin and coumarin derivates: Monitor prothrombin times when fluvastatin coadministration is initiated, discontinued, or the dosage changed ( 7 ) 7.1 Cyclosporine Cyclosporine coadministration increases fluvastatin exposure. Therefore, in...
Fluvastatin Also Interacts With
- Clarithromycin major
- Glyburide moderate
- Gemfibrozil moderate
- Niacin moderate
- Phenytoin moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Fluvastatin + Cyclosporine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Fluvastatin's 12. In the moderate band specifically: Fluvastatin has 6 (also Glyburide, Gemfibrozil, Niacin, Phenytoin); Cyclosporine has 24 (also Aliskiren, Allopurinol, Amiloride, Amlodipine/Valsartan).
What mechanism field is on file for Fluvastatin and Cyclosporine?
Cyclosporine makes it harder for your body to get rid of fluvastatin, leading to higher levels of the cholesterol medicine in your blood.
Cyclosporine carries more major-labeled pairs than Fluvastatin
SPL source-record counts only. This page's band is moderate · classes on file: Fluvastatin (HMG-CoA Reductase Inhibitor (Statin)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Fluvastatin's 1. This page itself is in the moderate band, not the major band.
1 major · 6 moderate · 5 minor · 12 total
- Other moderate peers for Fluvastatin
- Glyburide
- Gemfibrozil
- Niacin
- Phenytoin
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Aliskiren
- Allopurinol
- Amiloride
- Amlodipine/Valsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.