Fluvastatin and Phenytoin Interaction
Drug interaction information between Fluvastatin and Phenytoin.
Fluvastatin and Phenytoin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fluvastatin and Phenytoin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluvastatin can cause the levels of phenytoin in your blood to rise, which may lead to side effects.
FDA Label Information
Caution should be used when prescribing with fluvastatin ( 5.1 , 7.3 , 7.4 ) Glyburide: Monitor blood glucose levels when fluvastatin dose is changed ( 7 ) Phenytoin: Monitor plasma phenytoin levels when fluvastatin treatment is initiated or when the dosage is changed ( 7 ) Warfarin and coumarin derivates: Monitor prothrombin times when fluvastatin coadministration is initiated, discontinued, or the dosage changed ( 7 ) 7.1 Cyclosporine Cyclosporine coadministration increases fluvastatin exposure. 7.7 Phenytoin Concomitant administration of fluvastatin and phenytoin increased phenytoin...
Fluvastatin Also Interacts With
- Clarithromycin major
- Cyclosporine moderate
- Glyburide moderate
- Gemfibrozil moderate
- Niacin moderate
Phenytoin Also Interacts With
- Nirmatrelvir/Ritonavir major
- Posaconazole major
- Ranolazine major
- Voriconazole major
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Fluvastatin + Phenytoin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenytoin has 147 labeled pairs on file vs Fluvastatin's 12. In the moderate band specifically: Fluvastatin has 6 (also Cyclosporine, Glyburide, Gemfibrozil, Niacin); Phenytoin has 23 (also Apixaban, Aprepitant, Canagliflozin, Carbidopa/Levodopa).
What mechanism field is on file for Fluvastatin and Phenytoin?
Fluvastatin can cause the levels of phenytoin in your blood to rise, which may lead to side effects.
Phenytoin carries more major-labeled pairs than Fluvastatin
SPL source-record counts only. This page's band is moderate · classes on file: Fluvastatin (HMG-CoA Reductase Inhibitor (Statin)); Phenytoin (Anticonvulsant (Hydantoin)).
Phenytoin has 4 major-labeled pairs vs Fluvastatin's 1. This page itself is in the moderate band, not the major band.
1 major · 6 moderate · 5 minor · 12 total
- Other moderate peers for Fluvastatin
- Cyclosporine
- Glyburide
- Gemfibrozil
- Niacin
4 major · 23 moderate · 120 minor · 147 total
- Other moderate peers for Phenytoin
- Apixaban
- Aprepitant
- Canagliflozin
- Carbidopa/Levodopa
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.