What the FDA labels say about taking them together
Fluvastatin and phenytoin
Fluvastatin's FDA label of April 21, 2025 names phenytoin in its drug interactions section, and phenytoin's label names fluvastatin too. The fluvastatin label: “Clinical impact; Concomitant administration of fluvastatin and phenytoin increased phenytoin exposures.”
Check it at the source: the fluvastatin FDA label on DailyMed (effective April 21, 2025, Teva Pharmaceuticals USA, Inc.); the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.).
What does the fluvastatin label say about phenytoin?
Fluvastatin label, drug interactionsCaution should be used when prescribing with fluvastatin ( 5.1 , 7.3 , 7.4 ) Glyburide: Monitor blood glucose levels when fluvastatin dose is changed ( 7 ) Phenytoin:
Fluvastatin Sodium Er label (Sandoz Inc, January 31, 2024), drug interactionsClinical impact; Concomitant administration of fluvastatin and phenytoin increased phenytoin exposures [see Clinical Pharmacology ()].
Source: FDA drug label (Fluvastatin Sodium Er, NDA021192), Sandoz Inc, effective January 31, 2024 (SPL set 5ab4296c-87c2-4c64-b218-d620eef51310), via openFDA
Source: FDA drug label (Fluvastatin), Teva Pharmaceuticals USA, Inc., effective April 21, 2025 (SPL set aad8b373-0aec-4efb-8e61-3d8114b31127), via openFDA; the full label on DailyMed
What does the phenytoin label say about fluvastatin?
Phenytoin label, drug interactionsInteracting Agent: Other; Examples: Acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, disulfiram, estrogen, fluvastatin, isoniazid, methylphenidate, phenothiazines, salicylates, ticlopidine, tolbutamide, trazodone, warfarin
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluvastatin | Phenytoin | |
|---|---|---|
| Labeled for | High cholesterol | Seizures and epilepsy |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $2.88 per tablet 80 mg tablet | $0.145 per capsule 100 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once