Fluvastatin and Gemfibrozil Interaction
Drug interaction information between Fluvastatin and Gemfibrozil.
Fluvastatin and Gemfibrozil have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fluvastatin and Gemfibrozil. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Taking these two cholesterol medicines together can cause a dangerous breakdown of muscle tissue.
What To Do
You should avoid taking these two medications together.
FDA Label Information
7.3 Gemfibrozil Due to an increased risk of myopathy/rhabdomyolysis when HMG-CoA reductase inhibitors are coadministered with gemfibrozil, concomitant administration of fluvastatin sodium with gemfibrozil should be avoided.
Fluvastatin Also Interacts With
- Clarithromycin major
- Cyclosporine moderate
- Glyburide moderate
- Niacin moderate
- Phenytoin moderate
Gemfibrozil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Repaglinide major
- Simvastatin major
- Atorvastatin moderate
Frequently Asked Questions
Can I take Fluvastatin and Gemfibrozil together?
This is a moderate interaction. You should avoid taking these two medications together.
How serious is the interaction between Fluvastatin and Gemfibrozil?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Fluvastatin and Gemfibrozil interact?
Taking these two cholesterol medicines together can cause a dangerous breakdown of muscle tissue.
Understanding the Fluvastatin and Gemfibrozil Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Fluvastatin belongs to the HMG-CoA Reductase Inhibitor (Statin) class and Gemfibrozil belongs to the Fibrate class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Taking these two cholesterol medicines together can cause a dangerous breakdown of muscle tissue. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Fluvastatin has 12 total documented interactions on file in this dataset, and Gemfibrozil has 20. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You should avoid taking these two medications together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Fluvastatin or Gemfibrozil based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.