nebivolol vs verapamil
Side-by-side comparison of nebivolol and verapamil. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
( 7.3 ) Verapamil- or diltiazem-type calcium channel blockers may cause excessive reductions in heart rate, blood pressure, and cardiac contractility. 7.4 Calcium Channel Blockers Nebivolol can exacerbate the effects of myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists (particularly of the phenylalkylamine [verapamil] and benzothiazepine [diltiazem] classes), or antiarrhythmic agents, such as disopyramide.
Recommendation: Monitor your heart rate regularly and report any symptoms like dizziness or extreme tiredness to your healthcare provider.
Nebivolol is a medicine that lowers high blood pressure. Lowering blood pressure helps prevent strokes and heart attacks.
Verapamil is a drug that helps to lower blood pressure and treat chest pain (angina) and irregular heartbeats (arrhythmias). It works by relaxing blood vessels and slowing down the heart rate.
Nebivolol treats high blood pressure. High blood pressure increases your risk of heart attack and stroke. Nebivolol can be used alone or with other blood pressure medicines.
Verapamil is used to treat chest pain called angina. This includes angina that happens when you are resting or during normal activity. It is also used to control your heart rate if you have a fast or irregular heartbeat, such as atrial fibrillation or atrial flutter. Verapamil also treats high blood pressure.
Nebivolol is a beta-blocker that mainly affects the heart. It works by relaxing blood vessels and slowing down your heart rate. This makes it easier for your heart to pump blood and lowers blood pressure.
Verapamil belongs to a class of drugs called calcium channel blockers. It works by blocking calcium from entering heart and blood vessel cells. This relaxes and widens blood vessels, which lowers blood pressure and makes it easier for the heart to pump.
- • Headache
- • Tiredness
- • Dizziness
- • Diarrhea
- • Nausea
- • Constipation
- • Shortness of breath
- • Dizziness
- • Slow heart rate (less than 50 beats per minute)
- • Nausea
- Sudden kidney damage 922
- Difficulty breathing 773
- Diarrhea 724
- Interaction with another medicine 616
- Low blood pressure 610
- Shortness of breath 356
- Feeling sick to your stomach 341
- Interaction with another medicine 316
- Feeling lightheaded or unsteady 286
- Low blood pressure 280
Do not stop taking nebivolol suddenly if you have heart disease. This can make chest pain worse or cause a heart attack. Talk to your doctor before stopping nebivolol. They will likely lower your dose slowly over 1 to 2 weeks.
You should not take this medicine if you have severe heart problems, very low blood pressure, or certain types of irregular heartbeats without a pacemaker. Talk to your doctor if you have any of these conditions.
Talk to your doctor if you are pregnant or plan to become pregnant. Nebivolol may cause problems for the baby, such as low blood pressure or slow heart rate. Breastfeeding is not recommended while taking nebivolol.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if verapamil will harm your unborn baby. Verapamil can pass into breast milk, so talk to your doctor about the best way to feed your baby if you take this medicine.
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How to Read This nebivolol vs verapamil Comparison
nebivolol is classified in the Beta-1 Selective Blocker drug class, while verapamil sits within the Calcium Channel Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, nebivolol has 3,645 submissions while verapamil has 1,579. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these drugs both act on the heart to slow it down and lower blood pressure. combining them can cause your heart rate or blood pressure to drop to levels that are too low.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between nebivolol and verapamil - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.