Nabilone and Diazepam Interaction
Drug interaction information between Nabilone and Diazepam.
Nabilone and Diazepam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nabilone and Diazepam. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both drugs slow down the brain and body, which can lead to a combined effect that makes it much harder to move or think clearly.
What To Do
Be very careful when performing tasks that require focus, like driving, because this combination can cause severe impairment.
FDA Label Information
Drug Interactions Potential interactions between Cesamet 2 mg, and diazepam 5 mg; sodium secobarbital 100 mg; alcohol 45 mL (absolute laboratory alcohol); or codeine 65 mg, were evaluated in 15 subjects. Psychomotor function was particularly impaired with concurrent use of diazepam.
Nabilone Also Interacts With
- Fluoxetine minor
- Buspirone minor
- Amitriptyline minor
- Lithium minor
- Desipramine minor
Diazepam Also Interacts With
- Clonazepam moderate
- Fluoxetine moderate
- Mirtazapine moderate
- Raloxifene moderate
- Omeprazole minor
Frequently Asked Questions
Can I take Nabilone and Diazepam together?
This is a minor interaction. Be very careful when performing tasks that require focus, like driving, because this combination can cause severe impairment.
How serious is the interaction between Nabilone and Diazepam?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Nabilone and Diazepam interact?
Both drugs slow down the brain and body, which can lead to a combined effect that makes it much harder to move or think clearly.
Understanding the Nabilone and Diazepam Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Nabilone belongs to the Cannabinoid Antiemetic class and Diazepam belongs to the Benzodiazepine class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both drugs slow down the brain and body, which can lead to a combined effect that makes it much harder to move or think clearly. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Nabilone has 11 total documented interactions on file in this dataset, and Diazepam has 26. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Be very careful when performing tasks that require focus, like driving, because this combination can cause severe impairment. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Nabilone or Diazepam based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.