Nabilone and Desipramine Interaction
Drug interaction information between Nabilone and Desipramine.
Nabilone and Desipramine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nabilone and Desipramine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These drugs can work together to speed up your heart rate and raise your blood pressure while also making you feel sleepy.
What To Do
Your healthcare provider should check your heart rate and blood pressure regularly while you are on both medications.
FDA Label Information
CONCOMITANT DRUG CLINICAL EFFECT(S) Amphetamines, cocaine, other sympathomimetic agents Additive hypertension, tachycardia, possibly cardiotoxicity Atropine, scopolamine, antihistamines, other anticholinergic agents Additive or super-additive tachycardia, drowsiness Amitriptyline, amoxapine, desipramine, other tricyclic antidepressants Additive tachycardia, hypertension, drowsiness Barbiturates, benzodiazepines, ethanol, lithium, opioids, buspirone, antihistamines, muscle relaxants, other CNS depressants Additive drowsiness and CNS depression Disulfiram A reversible hypomanic reaction was...
Nabilone Also Interacts With
- Fluoxetine minor
- Buspirone minor
- Amitriptyline minor
- Diazepam minor
- Lithium minor
Desipramine Also Interacts With
- Atomoxetine minor
- Bupropion minor
- Darunavir minor
- Desvenlafaxine minor
- Dopamine minor
Frequently Asked Questions
Can I take Nabilone and Desipramine together?
This is a minor interaction. Your healthcare provider should check your heart rate and blood pressure regularly while you are on both medications.
How serious is the interaction between Nabilone and Desipramine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Nabilone and Desipramine interact?
These drugs can work together to speed up your heart rate and raise your blood pressure while also making you feel sleepy.
Understanding the Nabilone and Desipramine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Nabilone belongs to the Cannabinoid Antiemetic class and Desipramine belongs to the Tricyclic Antidepressant (TCA) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These drugs can work together to speed up your heart rate and raise your blood pressure while also making you feel sleepy. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Nabilone has 11 total documented interactions on file in this dataset, and Desipramine has 18. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your healthcare provider should check your heart rate and blood pressure regularly while you are on both medications. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Nabilone or Desipramine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.