Nabilone and Desipramine Interaction
Drug interaction information between Nabilone and Desipramine.
Nabilone and Desipramine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nabilone and Desipramine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs can work together to speed up your heart rate and raise your blood pressure while also making you feel sleepy.
FDA Label Information
CONCOMITANT DRUG CLINICAL EFFECT(S) Amphetamines, cocaine, other sympathomimetic agents Additive hypertension, tachycardia, possibly cardiotoxicity Atropine, scopolamine, antihistamines, other anticholinergic agents Additive or super-additive tachycardia, drowsiness Amitriptyline, amoxapine, desipramine, other tricyclic antidepressants Additive tachycardia, hypertension, drowsiness Barbiturates, benzodiazepines, ethanol, lithium, opioids, buspirone, antihistamines, muscle relaxants, other CNS depressants Additive drowsiness and CNS depression Disulfiram A reversible hypomanic reaction was...
Nabilone Also Interacts With
- Fluoxetine minor
- Buspirone minor
- Amitriptyline minor
- Diazepam minor
- Lithium minor
Desipramine Also Interacts With
- Atomoxetine minor
- Bupropion minor
- Darunavir minor
- Desvenlafaxine minor
- Dopamine minor
Frequently Asked Questions
What SPL severity band is on file for Nabilone + Desipramine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Desipramine has 18 labeled pairs on file vs Nabilone's 11. In the minor band specifically: Nabilone has 11 (also Fluoxetine, Buspirone, Amitriptyline, Diazepam); Desipramine has 18 (also Atomoxetine, Bupropion, Darunavir, Desvenlafaxine).
What mechanism field is on file for Nabilone and Desipramine?
These drugs can work together to speed up your heart rate and raise your blood pressure while also making you feel sleepy.
Desipramine's labeled portfolio outnumbers Nabilone
SPL source-record counts only. This page's band is minor · classes on file: Nabilone (Cannabinoid Antiemetic); Desipramine (Tricyclic Antidepressant (TCA)).
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Nabilone
- Fluoxetine
- Buspirone
- Amitriptyline
- Diazepam
0 major · 0 moderate · 18 minor · 18 total
- Other minor peers for Desipramine
- Atomoxetine
- Bupropion
- Darunavir
- Desvenlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.