Nabilone and Fluoxetine Interaction
Drug interaction information between Nabilone and Fluoxetine.
Nabilone and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nabilone and Fluoxetine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both of these drugs affect the brain and can cause an increased level of sleepiness when taken at the same time.
What To Do
Monitor yourself for extreme drowsiness and avoid activities like driving until you know how the combination affects you.
FDA Label Information
CONCOMITANT DRUG CLINICAL EFFECT(S) Amphetamines, cocaine, other sympathomimetic agents Additive hypertension, tachycardia, possibly cardiotoxicity Atropine, scopolamine, antihistamines, other anticholinergic agents Additive or super-additive tachycardia, drowsiness Amitriptyline, amoxapine, desipramine, other tricyclic antidepressants Additive tachycardia, hypertension, drowsiness Barbiturates, benzodiazepines, ethanol, lithium, opioids, buspirone, antihistamines, muscle relaxants, other CNS depressants Additive drowsiness and CNS depression Disulfiram A reversible hypomanic reaction was...
Nabilone Also Interacts With
- Buspirone minor
- Amitriptyline minor
- Diazepam minor
- Lithium minor
- Desipramine minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
Can I take Nabilone and Fluoxetine together?
This is a minor interaction. Monitor yourself for extreme drowsiness and avoid activities like driving until you know how the combination affects you.
How serious is the interaction between Nabilone and Fluoxetine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Nabilone and Fluoxetine interact?
Both of these drugs affect the brain and can cause an increased level of sleepiness when taken at the same time.
Understanding the Nabilone and Fluoxetine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Nabilone belongs to the Cannabinoid Antiemetic class and Fluoxetine belongs to the Selective Serotonin Reuptake Inhibitor (SSRI) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both of these drugs affect the brain and can cause an increased level of sleepiness when taken at the same time. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Nabilone has 11 total documented interactions on file in this dataset, and Fluoxetine has 68. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Monitor yourself for extreme drowsiness and avoid activities like driving until you know how the combination affects you. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Nabilone or Fluoxetine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.