Nabilone and Buspirone Interaction
Drug interaction information between Nabilone and Buspirone.
Nabilone and Buspirone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nabilone and Buspirone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These medications both slow down the central nervous system, which can lead to a combined effect of increased tiredness or dizziness.
What To Do
Use caution when taking these together and tell your doctor if you feel unusually sleepy or lightheaded.
FDA Label Information
CONCOMITANT DRUG CLINICAL EFFECT(S) Amphetamines, cocaine, other sympathomimetic agents Additive hypertension, tachycardia, possibly cardiotoxicity Atropine, scopolamine, antihistamines, other anticholinergic agents Additive or super-additive tachycardia, drowsiness Amitriptyline, amoxapine, desipramine, other tricyclic antidepressants Additive tachycardia, hypertension, drowsiness Barbiturates, benzodiazepines, ethanol, lithium, opioids, buspirone, antihistamines, muscle relaxants, other CNS depressants Additive drowsiness and CNS depression Disulfiram A reversible hypomanic reaction was...
Nabilone Also Interacts With
- Fluoxetine minor
- Amitriptyline minor
- Diazepam minor
- Lithium minor
- Desipramine minor
Buspirone Also Interacts With
- Tranylcypromine moderate
- Ziprasidone moderate
- Citalopram minor
- Darunavir minor
- Desvenlafaxine minor
Frequently Asked Questions
Can I take Nabilone and Buspirone together?
This is a minor interaction. Use caution when taking these together and tell your doctor if you feel unusually sleepy or lightheaded.
How serious is the interaction between Nabilone and Buspirone?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Nabilone and Buspirone interact?
These medications both slow down the central nervous system, which can lead to a combined effect of increased tiredness or dizziness.
Understanding the Nabilone and Buspirone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Nabilone belongs to the Cannabinoid Antiemetic class and Buspirone belongs to the Azapirone Anxiolytic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These medications both slow down the central nervous system, which can lead to a combined effect of increased tiredness or dizziness. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Nabilone has 11 total documented interactions on file in this dataset, and Buspirone has 17. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Use caution when taking these together and tell your doctor if you feel unusually sleepy or lightheaded. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Nabilone or Buspirone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.