Nabilone and Buspirone Interaction
Drug interaction information between Nabilone and Buspirone.
Nabilone and Buspirone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nabilone and Buspirone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications both slow down the central nervous system, which can lead to a combined effect of increased tiredness or dizziness.
FDA Label Information
CONCOMITANT DRUG CLINICAL EFFECT(S) Amphetamines, cocaine, other sympathomimetic agents Additive hypertension, tachycardia, possibly cardiotoxicity Atropine, scopolamine, antihistamines, other anticholinergic agents Additive or super-additive tachycardia, drowsiness Amitriptyline, amoxapine, desipramine, other tricyclic antidepressants Additive tachycardia, hypertension, drowsiness Barbiturates, benzodiazepines, ethanol, lithium, opioids, buspirone, antihistamines, muscle relaxants, other CNS depressants Additive drowsiness and CNS depression Disulfiram A reversible hypomanic reaction was...
Nabilone Also Interacts With
- Fluoxetine minor
- Amitriptyline minor
- Diazepam minor
- Lithium minor
- Desipramine minor
Buspirone Also Interacts With
- Tranylcypromine moderate
- Ziprasidone moderate
- Citalopram minor
- Darunavir minor
- Desvenlafaxine minor
Frequently Asked Questions
What SPL severity band is on file for Nabilone + Buspirone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Buspirone has 17 labeled pairs on file vs Nabilone's 11. In the minor band specifically: Nabilone has 11 (also Fluoxetine, Amitriptyline, Diazepam, Lithium); Buspirone has 15 (also Citalopram, Darunavir, Desvenlafaxine, Diltiazem).
What mechanism field is on file for Nabilone and Buspirone?
These medications both slow down the central nervous system, which can lead to a combined effect of increased tiredness or dizziness.
Buspirone's labeled portfolio outnumbers Nabilone
SPL source-record counts only. This page's band is minor · classes on file: Nabilone (Cannabinoid Antiemetic); Buspirone (Azapirone Anxiolytic).
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Nabilone
- Fluoxetine
- Amitriptyline
- Diazepam
- Lithium
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Buspirone
- Citalopram
- Darunavir
- Desvenlafaxine
- Diltiazem
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.