montelukast vs prednisolone
Side-by-side comparison of montelukast and prednisolone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
DRUG INTERACTIONS No dose adjustment is needed when montelukast sodium is co-administered with theophylline, prednisone, prednisolone, oral contraceptives, terfenadine, digoxin, warfarin, gemfibrozil, itraconazole, thyroid hormones, sedative hypnotics, non-steroidal anti-inflammatory agents, benzodiazepines, decongestants, and Cytochrome P450 (CYP) enzyme inducers [see Clinical Pharmacology (12.3)] .
Recommendation: You can safely take these medicines together without adjusting your current dosages.
Singulair
Orapred, Pediapred
Montelukast is a medicine that helps control asthma and allergies. It works by blocking certain natural substances in your body that cause asthma and allergy symptoms.
Prednisolone eye drops reduce inflammation in your eye. It is a type of steroid medicine.
Montelukast is used to prevent asthma symptoms and treat long-term asthma. It can also prevent breathing problems caused by exercise. Additionally, it helps relieve symptoms of allergies like sneezing, runny nose, and itchy eyes, both seasonal and year-round.
This medicine treats swelling and redness in your eye. It can help with problems of the conjunctiva, cornea, and other parts of the front of your eye. It is used when the swelling responds to steroid treatment.
This medicine blocks leukotrienes, which are substances your body releases that cause swelling in the lungs and tightening of the muscles around your airways. By blocking these substances, montelukast helps you breathe easier. It also reduces allergy symptoms.
Prednisolone is a corticosteroid. It works by reducing inflammation in the eye. This helps to relieve redness, swelling, and pain.
- • Upper respiratory infection
- • Fever
- • Headache
- • Sore throat
- • Cough
- • Eye pain
- • Feeling like something is in your eye
- • Headache
- • Itching
- • Rash
- Difficulty breathing 7,724
- Asthma 7,439
- Tiredness 5,505
- Headache 4,785
- Cough 4,617
- Fever 8,198
- Difficulty breathing 6,809
- Lung infection 6,760
- Loose or watery stools 6,510
- Condition is getting worse 5,689
Do not use montelukast to treat a sudden asthma attack. Always have your rescue medicine with you. Do not suddenly stop taking steroid medicines if you are also taking montelukast. Some patients have experienced changes in behavior or mood, including suicidal thoughts. Tell your doctor right away if you notice these changes.
Using steroid eye drops for a long time may cause glaucoma (increased pressure in the eye) or cataracts. It can also make it harder for your eye to heal if you have an injury. Tell your doctor if your symptoms do not improve after 2 days.
If you are pregnant, talk to your doctor before taking montelukast. It is not known if montelukast passes into breast milk, so talk to your doctor if you are breastfeeding.
Tell your doctor if you are pregnant or breastfeeding. It is not known if prednisolone eye drops will harm an unborn baby. Talk to your doctor about the risks and benefits.
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How to Read This montelukast vs prednisolone Comparison
montelukast is classified in the Leukotriene Receptor Antagonist drug class, while prednisolone sits within the Corticosteroid class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, montelukast has 30,070 submissions while prednisolone has 33,966. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to there is no evidence that these medicines affect each other's levels or performance in the body.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between montelukast and prednisolone - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.