Mometasone and Darunavir Interaction
Drug interaction information between Mometasone and Darunavir.
Mometasone and Darunavir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Mometasone and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir slows down how fast your body gets rid of mometasone, which can cause the steroid to reach dangerously high levels.
FDA Label Information
betamethasone budesonide ciclesonide fluticasone methylprednisolone mometasone triamcinolone ↑ corticosteroids Co-administration with corticosteroids (all routes of administration) of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression.
Mometasone Also Interacts With
- Nirmatrelvir/Ritonavir moderate
- Mometasone Topical minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Mometasone + Darunavir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Mometasone's 3. In the moderate band specifically: Mometasone has 2 (also Nirmatrelvir/Ritonavir); Darunavir has 16 (also Omeprazole, Fluticasone, Apixaban, Clopidogrel).
What mechanism field is on file for Mometasone and Darunavir?
Darunavir slows down how fast your body gets rid of mometasone, which can cause the steroid to reach dangerously high levels.
Darunavir carries more major-labeled pairs than Mometasone
SPL source-record counts only. This page's band is moderate · classes on file: Mometasone (Inhaled Corticosteroid); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Mometasone's 0. This page itself is in the moderate band, not the major band.
0 major · 2 moderate · 1 minor · 3 total
- Other moderate peers for Mometasone
- Nirmatrelvir/Ritonavir
15 major · 16 moderate · 70 minor · 101 total
- Other moderate peers for Darunavir
- Omeprazole
- Fluticasone
- Apixaban
- Clopidogrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.