Mirtazapine and Selegiline Interaction
Drug interaction information between Mirtazapine and Selegiline.
Mirtazapine and Selegiline have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Mirtazapine and Selegiline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both mirtazapine and selegiline increase the amount of serotonin in your brain. Combining them can lead to a toxic buildup of this chemical.
FDA Label Information
Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact The concomitant use of serotonergic drugs with mirtazapine increases the risk of serotonin syndrome.
Mirtazapine Also Interacts With
- Linezolid major
- Alprazolam moderate
- Diazepam moderate
- Phenelzine moderate
- Tranylcypromine moderate
Selegiline Also Interacts With
- Desvenlafaxine moderate
- Levomilnacipran moderate
- Paroxetine moderate
- Trazodone moderate
- Vortioxetine moderate
Frequently Asked Questions
What SPL severity band is on file for Mirtazapine + Selegiline?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Mirtazapine has 29 labeled pairs on file vs Selegiline's 9. In the moderate band specifically: Mirtazapine has 5 (also Alprazolam, Diazepam, Phenelzine, Tranylcypromine); Selegiline has 6 (also Desvenlafaxine, Levomilnacipran, Paroxetine, Trazodone).
What mechanism field is on file for Mirtazapine and Selegiline?
Both mirtazapine and selegiline increase the amount of serotonin in your brain. Combining them can lead to a toxic buildup of this chemical.
Mirtazapine carries more major-labeled pairs than Selegiline
SPL source-record counts only. This page's band is moderate · classes on file: Mirtazapine (Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)); Selegiline (Selective MAO-B Inhibitor).
Mirtazapine has 1 major-labeled pair vs Selegiline's 0. This page itself is in the moderate band, not the major band.
1 major · 5 moderate · 23 minor · 29 total
- Other moderate peers for Mirtazapine
- Alprazolam
- Diazepam
- Phenelzine
- Tranylcypromine
0 major · 6 moderate · 3 minor · 9 total
- Other moderate peers for Selegiline
- Desvenlafaxine
- Levomilnacipran
- Paroxetine
- Trazodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.