metoclopramide vs tacrolimus topical
Side-by-side comparison of metoclopramide and tacrolimus topical. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Other drugs, such as: Magnesium and aluminum hydroxide antacids Metoclopramide May increase tacrolimus whole blood trough concentrations and increase the risk of serious adverse reactions (e.g., neurotoxicity, QT prolongation) [see Warnings and Precautions ( 5.7 , 5.10 , 5.11 )] .
Recommendation: Your doctor should monitor your blood levels and may need to change your dose. Be alert for any new health problems while taking these together.
Reglan
Protopic
Metoclopramide is a drug that helps with stomach problems. It can help food move faster through your stomach and reduce nausea.
Tacrolimus extended-release capsules help prevent organ rejection in kidney transplant patients. It works by suppressing your immune system.
This medicine treats heartburn caused by acid reflux when other treatments don't work. It also helps with symptoms of slow stomach emptying in people with diabetes, like nausea, vomiting, and feeling full. This medicine is for adults and should not be used for more than 12 weeks.
This medicine is used to prevent your body from rejecting a new kidney after a transplant. It is for adult patients who can swallow capsules whole. You will take it with other medicines that also suppress your immune system.
Metoclopramide helps your stomach muscles move faster. This helps food empty from your stomach more quickly. It also blocks a chemical in your brain that causes nausea.
Tacrolimus belongs to a class of drugs called calcineurin inhibitors. It lowers the activity of your immune system. This helps prevent your body from attacking your new kidney.
- • Restlessness
- • Drowsiness
- • Fatigue
- • Feeling tired
- • Diarrhea
- • Constipation
- • Nausea
- • Swelling in your arms and legs
- • Tremors
- Uncontrollable muscle movements 13,205
- Movement problems 11,628
- Problem with the brain or nerves 7,175
- Muscle spasms 6,661
- Pain 4,665
No adverse event reports.
Metoclopramide can cause a serious movement disorder called tardive dyskinesia. This may not go away even after you stop taking the medicine. The risk of tardive dyskinesia increases with long-term use and high doses. Call your doctor right away if you have uncontrolled muscle movements.
This medicine can increase your risk of serious infections and certain cancers. These problems could lead to hospitalization or even death. This drug is not approved for liver transplants and may increase the risk of death in female liver transplant patients.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if this medicine will harm your unborn baby. Talk to your doctor about the risks and benefits of taking this medicine while breastfeeding.
Tacrolimus can harm your unborn baby. Tell your doctor right away if you are pregnant or plan to become pregnant. There is a pregnancy registry to track outcomes in women who take tacrolimus during pregnancy.
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How to Read This metoclopramide vs tacrolimus topical Comparison
metoclopramide is classified in the Prokinetic / Antiemetic drug class, while tacrolimus topical sits within the Calcineurin Inhibitor (Topical) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, metoclopramide has 43,334 submissions while tacrolimus topical has 0. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to metoclopramide can cause the amount of tacrolimus in your blood to increase. this makes it more likely that you will experience serious side effects from the medication.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between metoclopramide and tacrolimus topical - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.