Methadone and Itraconazole Interaction
Drug interaction information between Methadone and Itraconazole.
Methadone and Itraconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Methadone and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole prevents your body from clearing methadone, which can lead to a dangerous buildup and breathing issues.
FDA Label Information
Analgesics Methadone Contraindicated during and 2 weeks after itraconazole treatment.
Methadone Also Interacts With
- Safinamide major
- Phenobarbital moderate
- Tranylcypromine moderate
- Gabapentin minor
- Sertraline minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Midazolam major
- Felodipine major
Frequently Asked Questions
What SPL severity band is on file for Methadone + Itraconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Methadone's 41. In the major band specifically: Methadone has 2 (also Safinamide); Itraconazole has 19 (also Isavuconazonium, Lurasidone, Pimozide, Midazolam).
What mechanism field is on file for Methadone and Itraconazole?
Itraconazole prevents your body from clearing methadone, which can lead to a dangerous buildup and breathing issues.
Itraconazole carries more major-labeled pairs than Methadone
SPL source-record counts only. This page's band is major · classes on file: Methadone (Opioid Agonist); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Methadone's 2.
19 major · 20 moderate · 77 minor · 116 total
- Other major peers for Itraconazole
- Isavuconazonium
- Lurasidone
- Pimozide
- Midazolam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.