Methadone and Gabapentin Interaction
Drug interaction information between Methadone and Gabapentin.
Methadone and Gabapentin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Methadone and Gabapentin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines can slow down your brain activity and breathing, which increases the risk of dangerous sleepiness.
FDA Label Information
Examples: Benzodiazepines and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, alcohol.
Methadone Also Interacts With
- Itraconazole major
- Safinamide major
- Phenobarbital moderate
- Tranylcypromine moderate
- Sertraline minor
Gabapentin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Oxycodone minor
- Estradiol minor
- Naproxen minor
- Norethindrone minor
Frequently Asked Questions
What SPL severity band is on file for Methadone + Gabapentin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methadone has 41 labeled pairs on file vs Gabapentin's 19. In the minor band specifically: Methadone has 37 (also Sertraline, Trazodone, Tramadol, Cyclobenzaprine); Gabapentin has 18 (also Oxycodone, Estradiol, Naproxen, Norethindrone).
What mechanism field is on file for Methadone and Gabapentin?
Both of these medicines can slow down your brain activity and breathing, which increases the risk of dangerous sleepiness.
Methadone carries more major-labeled pairs than Gabapentin
SPL source-record counts only. This page's band is minor · classes on file: Methadone (Opioid Agonist); Gabapentin (Anticonvulsant / Nerve Pain Agent).
Methadone has 2 major-labeled pairs vs Gabapentin's 0. This page itself is in the minor band, not the major band.
2 major · 2 moderate · 37 minor · 41 total
- Other minor peers for Methadone
- Sertraline
- Trazodone
- Tramadol
- Cyclobenzaprine
0 major · 1 moderate · 18 minor · 19 total
- Other minor peers for Gabapentin
- Oxycodone
- Estradiol
- Naproxen
- Norethindrone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.