Methadone and Safinamide Interaction
Drug interaction information between Methadone and Safinamide.
Methadone and Safinamide have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Methadone and Safinamide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these together can cause a very serious and potentially fatal reaction in the brain and nervous system.
FDA Label Information
7.2 Opioid Drugs Because serious, sometimes fatal reactions have been precipitated with concomitant use of opioid drugs (e.g., meperidine and its derivatives, methadone, propoxyphene, or tramadol) and MAOIs, including selective MAO-B inhibitors, concomitant use of these drugs is contraindicated [see Warnings and Precautions (5.2) ] .
Methadone Also Interacts With
- Itraconazole major
- Phenobarbital moderate
- Tranylcypromine moderate
- Gabapentin minor
- Sertraline minor
Safinamide Also Interacts With
- Tramadol major
- Methylphenidate major
- Linezolid major
- Meperidine major
- Dextromethorphan major
Frequently Asked Questions
What SPL severity band is on file for Methadone + Safinamide?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methadone has 41 labeled pairs on file vs Safinamide's 10. In the major band specifically: Methadone has 2 (also Itraconazole); Safinamide has 6 (also Tramadol, Methylphenidate, Linezolid, Meperidine).
What mechanism field is on file for Methadone and Safinamide?
Taking these together can cause a very serious and potentially fatal reaction in the brain and nervous system.
Safinamide carries more major-labeled pairs than Methadone
SPL source-record counts only. This page's band is major · classes on file: Methadone (Opioid Agonist); Safinamide (MAO-B Inhibitor).
Safinamide has 6 major-labeled pairs vs Methadone's 2.
6 major · 0 moderate · 4 minor · 10 total
- Other major peers for Safinamide
- Tramadol
- Methylphenidate
- Linezolid
- Meperidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.