Methadone and Tranylcypromine Interaction
Drug interaction information between Methadone and Tranylcypromine.
Methadone and Tranylcypromine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Methadone and Tranylcypromine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
This combination can lead to life-threatening issues like extremely high blood pressure or serotonin syndrome. These drugs interfere with the way the body processes chemicals that regulate pain, mood, and heart rate.
What To Do
It is best to avoid taking these drugs together. If they are necessary, your doctor will need to monitor you very closely for any signs of a bad reaction and use the lowest effective doses.
FDA Label Information
Product Clinical Comment on Concomitant Use [See Contraindications (4.1)] ; Predominant Effect/Risk [Hypertensive Reaction (HR) [See Warnings and Precautions (5.3)] ; or Serotonin Syndrome (SS) [See Warnings and Precautions (5.7)] ] Altretamine Use with caution If not otherwise specified in this table, consider avoiding concomitant use (see also information on medication-free intervals , use agent at the lowest appropriate dose, monitor for effects of the interaction, advise the patient to report potential effects, and be prepared to discontinue the agent and treat effects of the...
Methadone Also Interacts With
- Itraconazole major
- Safinamide major
- Phenobarbital moderate
- Gabapentin minor
- Sertraline minor
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
Frequently Asked Questions
Can I take Methadone and Tranylcypromine together?
This is a moderate interaction. It is best to avoid taking these drugs together. If they are necessary, your doctor will need to monitor you very closely for any signs of a bad reaction and use the lowest effective doses.
How serious is the interaction between Methadone and Tranylcypromine?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Methadone and Tranylcypromine interact?
This combination can lead to life-threatening issues like extremely high blood pressure or serotonin syndrome. These drugs interfere with the way the body processes chemicals that regulate pain, mood, and heart rate.
Understanding the Methadone and Tranylcypromine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Methadone belongs to the Opioid Agonist class and Tranylcypromine belongs to the Monoamine Oxidase Inhibitor (MAOI) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: This combination can lead to life-threatening issues like extremely high blood pressure or serotonin syndrome. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Methadone has 41 total documented interactions on file in this dataset, and Tranylcypromine has 42. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: It is best to avoid taking these drugs together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Methadone or Tranylcypromine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.