Methadone and Tranylcypromine Interaction
Drug interaction information between Methadone and Tranylcypromine.
Methadone and Tranylcypromine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Methadone and Tranylcypromine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination can lead to life-threatening issues like extremely high blood pressure or serotonin syndrome. These drugs interfere with the way the body processes chemicals that regulate pain, mood, and heart rate.
FDA Label Information
Product Clinical Comment on Concomitant Use [See Contraindications (4.1)] ; Predominant Effect/Risk [Hypertensive Reaction (HR) [See Warnings and Precautions (5.3)] ; or Serotonin Syndrome (SS) [See Warnings and Precautions (5.7)] ] Altretamine Use with caution If not otherwise specified in this table, consider avoiding concomitant use (see also information on medication-free intervals , use agent at the lowest appropriate dose, monitor for effects of the interaction, advise the patient to report potential effects, and be prepared to discontinue the agent and treat effects of the...
Methadone Also Interacts With
- Itraconazole major
- Safinamide major
- Phenobarbital moderate
- Gabapentin minor
- Sertraline minor
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
Frequently Asked Questions
What SPL severity band is on file for Methadone + Tranylcypromine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tranylcypromine has 42 labeled pairs on file vs Methadone's 41. In the moderate band specifically: Methadone has 2 (also Phenobarbital); Tranylcypromine has 23 (also Buspirone, Cyclobenzaprine, Carbamazepine, Lithium).
What mechanism field is on file for Methadone and Tranylcypromine?
This combination can lead to life-threatening issues like extremely high blood pressure or serotonin syndrome. These drugs interfere with the way the body processes chemicals that regulate pain, mood, and heart rate.
Tranylcypromine carries more major-labeled pairs than Methadone
SPL source-record counts only. This page's band is moderate · classes on file: Methadone (Opioid Agonist); Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)).
Tranylcypromine has 7 major-labeled pairs vs Methadone's 2. This page itself is in the moderate band, not the major band.
2 major · 2 moderate · 37 minor · 41 total
- Other moderate peers for Methadone
- Phenobarbital
7 major · 23 moderate · 12 minor · 42 total
- Other moderate peers for Tranylcypromine
- Buspirone
- Cyclobenzaprine
- Carbamazepine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.