itraconazole vs methadone
Side-by-side comparison of itraconazole and methadone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Analgesics Methadone Contraindicated during and 2 weeks after itraconazole treatment.
Recommendation: Do not use these medications together, and wait two weeks after your last dose of itraconazole before taking methadone.
Sporanox
Dolophine
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
Methadone Hydrochloride Injection is a strong pain medicine. It is also used to treat opioid dependence temporarily when you cannot take medicine by mouth.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
This medicine is used to manage severe, ongoing pain that needs a strong opioid medicine when other pain medicines don't work well enough. It is also used for the short-term treatment of opioid dependence when you cannot take oral medication, such as if you are in the hospital. Injectable methadone is not approved for outpatient treatment of opioid dependence.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
Methadone works by attaching to opioid receptors in the brain and body. This changes how your body feels pain. It can also help reduce withdrawal symptoms if you are opioid dependent.
- • Nausea
- • Rash
- • Headache
- • Lightheadedness
- • Dizziness
- • Sedation
- • Nausea
- • Vomiting
- Interaction with another medicine 1,118
- Fever 570
- Difficulty breathing 472
- Lung infection 462
- Feeling sick to your stomach 446
- Addiction to the drug 5,614
- Harmful effects from different substances 5,213
- Misuse of the drug 4,797
- Taking too much of the drug 3,841
- Pain 3,669
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
Methadone Hydrochloride Injection can cause serious and life-threatening risks, including addiction, abuse, and misuse. It can also cause life-threatening breathing problems, especially when you first start taking it or after a dose increase. Using methadone during pregnancy can cause withdrawal symptoms in the newborn. Using methadone with benzodiazepines or other drugs that can cause drowsiness, including alcohol, can cause severe sedation, breathing problems, coma, and death. Methadone can also cause a serious heart problem called QT prolongation.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
Using Methadone Hydrochloride Injection during pregnancy can cause withdrawal symptoms in the newborn. Talk to your doctor about the risks and benefits of using this medicine if you are pregnant or plan to become pregnant. It is not known if methadone passes into breast milk, so talk to your doctor before breastfeeding.
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How to Read This itraconazole vs methadone Comparison
itraconazole is classified in the Azole Antifungal drug class, while methadone sits within the Opioid Agonist class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, itraconazole has 3,068 submissions while methadone has 23,134. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to itraconazole prevents your body from clearing methadone, which can lead to a dangerous buildup and breathing issues.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between itraconazole and methadone - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.