Topiramate and Hydrochlorothiazide Interaction
Drug interaction information between Topiramate and Hydrochlorothiazide.
Topiramate and Hydrochlorothiazide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Topiramate and Hydrochlorothiazide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Adding this water pill can cause the levels of topiramate in your blood to increase.
FDA Label Information
7.5 Hydrochlorothiazide (HCTZ) Topiramate C max and AUC increased when HCTZ was added to topiramate.
Topiramate Also Interacts With
- Zonisamide moderate
- Alogliptin moderate
- Ertugliflozin moderate
- Amitriptyline minor
- Pioglitazone minor
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Hydrochlorothiazide/Triamterene major
- Lisinopril major
- Olmesartan moderate
- Losartan minor
Frequently Asked Questions
What SPL severity band is on file for Topiramate + Hydrochlorothiazide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Hydrochlorothiazide has 31 labeled pairs on file vs Topiramate's 30. In the minor band specifically: Topiramate has 27 (also Amitriptyline, Pioglitazone, Carbamazepine, Lithium); Hydrochlorothiazide has 27 (also Losartan, Spironolactone, Propranolol, Lithium).
What mechanism field is on file for Topiramate and Hydrochlorothiazide?
Adding this water pill can cause the levels of topiramate in your blood to increase.
Hydrochlorothiazide carries more major-labeled pairs than Topiramate
SPL source-record counts only. This page's band is minor · classes on file: Topiramate (Anticonvulsant); Hydrochlorothiazide (Thiazide Diuretic).
Hydrochlorothiazide has 3 major-labeled pairs vs Topiramate's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 27 minor · 30 total
- Other minor peers for Topiramate
- Amitriptyline
- Pioglitazone
- Carbamazepine
- Lithium
3 major · 1 moderate · 27 minor · 31 total
- Other minor peers for Hydrochlorothiazide
- Losartan
- Spironolactone
- Propranolol
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.