What the FDA labels say about taking them together
Hydrochlorothiazide and topiramate
Topiramate's FDA label of June 1, 2026 names hydrochlorothiazide in its drug interactions section; the hydrochlorothiazide labels PlainMeds reads (3) do not name topiramate. The topiramate label: “Hydrochlorothiazide (HCTZ) Topiramate Cmax and AUC increased when HCTZ was added to topiramate.”
Check it at the source: the hydrochlorothiazide FDA label on DailyMed (effective June 12, 2026, Leading Pharma, LLC); the topiramate FDA label on DailyMed (effective June 1, 2026, Sun Pharmaceutical Industries, Inc.).
What does the hydrochlorothiazide label say about topiramate?
Hydrochlorothiazide's label (effective June 12, 2026) and its 2 other brand-application labels do not name topiramate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (HYDROCHLOROTHIAZIDE), Leading Pharma, LLC, effective June 12, 2026 (SPL set 8c868894-667e-4a51-906a-838d63e420ba), via openFDA; the full label on DailyMed
What does the topiramate label say about hydrochlorothiazide?
Topiramate label, drug interactionsHydrochlorothiazide (HCTZ) Topiramate Cmax and AUC increased when HCTZ was added to topiramate.
Source: FDA drug label (Qudexy Xr, NDA205122), Upsher-Smith Laboratories, LLC, effective September 3, 2026 (SPL set 46f54677-3a22-4c38-9b92-923020164e15), via openFDA
Source: FDA drug label (Eprontia, NDA214679), Azurity Pharmaceuticals, Inc., effective November 13, 2025 (SPL set e2a4df59-fead-4a01-9021-9eda02c48010), via openFDA
Source: FDA drug label (Topiramate), Sun Pharmaceutical Industries, Inc., effective June 1, 2026 (SPL set 3c909a53-ae66-4b28-a741-b60bb25a69cf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Hydrochlorothiazide | Topiramate | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure, Edema (fluid retention) | Seizures and epilepsy, Migraine |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0115 per tablet 25 mg tablet | $0.0567 per tablet 100 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once