What the FDA labels say about taking them together
Pioglitazone and topiramate
Pioglitazone's FDA label of March 28, 2025 names topiramate in its drug interactions section, and topiramate's label names pioglitazone too. The pioglitazone label: “Topiramate may decrease pioglitazone concentrations.”
Check it at the source: the pioglitazone FDA label on DailyMed (effective March 28, 2025, Takeda Pharmaceuticals America, Inc.); the topiramate FDA label on DailyMed (effective June 1, 2026, Sun Pharmaceutical Industries, Inc.).
What does the pioglitazone label say about topiramate?
Pioglitazone label, drug interactionsTopiramate may decrease pioglitazone concentrations.
Source: FDA drug label (Actos), Takeda Pharmaceuticals America, Inc., effective March 28, 2025 (SPL set d2ddc491-88a9-4063-9150-443b4fa4330c), via openFDA; the full label on DailyMed
What does the topiramate label say about pioglitazone?
Topiramate label, drug interactionsPioglitazone A decrease in the exposure of pioglitazone and its active metabolites were noted with the concurrent use of pioglitazone and topiramatein a clinical trial.
Source: FDA drug label (Qudexy Xr, NDA205122), Upsher-Smith Laboratories, LLC, effective September 3, 2026 (SPL set 46f54677-3a22-4c38-9b92-923020164e15), via openFDA
Source: FDA drug label (Eprontia, NDA214679), Azurity Pharmaceuticals, Inc., effective November 13, 2025 (SPL set e2a4df59-fead-4a01-9021-9eda02c48010), via openFDA
Source: FDA drug label (Topiramate), Sun Pharmaceutical Industries, Inc., effective June 1, 2026 (SPL set 3c909a53-ae66-4b28-a741-b60bb25a69cf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pioglitazone | Topiramate | |
|---|---|---|
| Labeled for | Type 2 diabetes | Seizures and epilepsy, Migraine |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0675 per tablet 15 mg tablet | $0.0567 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once