Topiramate and Alogliptin Interaction
Drug interaction information between Topiramate and Alogliptin.
Topiramate and Alogliptin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Topiramate and Alogliptin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Topiramate can stop your kidneys from clearing metformin properly, which may cause the drug to build up to dangerous levels.
FDA Label Information
Examples: Topiramate, zonisamide, acetazolamide or dichlorphenamide Drugs that Reduce Metformin Clearance Clinical Impact: Concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT2]/multidrug and toxin extrusion [MATE] inhibitors) could increase systemic exposure to metformin and may increase the risk for lactic acidosis [see Clinical Pharmacology (12.3) ] .
Topiramate Also Interacts With
- Zonisamide moderate
- Ertugliflozin moderate
- Hydrochlorothiazide minor
- Amitriptyline minor
- Pioglitazone minor
Alogliptin Also Interacts With
- Zonisamide moderate
- Metformin minor
- Dolutegravir minor
- Ranolazine minor
- Cimetidine minor
Frequently Asked Questions
What SPL severity band is on file for Topiramate + Alogliptin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Topiramate has 30 labeled pairs on file vs Alogliptin's 7. In the moderate band specifically: Topiramate has 3 (also Zonisamide, Ertugliflozin); Alogliptin has 2 (also Zonisamide).
What mechanism field is on file for Topiramate and Alogliptin?
Topiramate can stop your kidneys from clearing metformin properly, which may cause the drug to build up to dangerous levels.
Topiramate's labeled portfolio outnumbers Alogliptin
SPL source-record counts only. This page's band is moderate · classes on file: Topiramate (Anticonvulsant); Alogliptin (DPP-4 Inhibitor).
0 major · 3 moderate · 27 minor · 30 total
- Other moderate peers for Topiramate
- Zonisamide
- Ertugliflozin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.