Meloxicam and Propranolol Interaction
Drug interaction information between Meloxicam and Propranolol.
Meloxicam and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Meloxicam and Propranolol. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Meloxicam can reduce the blood-pressure-lowering effects of propranolol. This makes your blood pressure medicine less effective.
What To Do
Your doctor should monitor your blood pressure closely. They may need to adjust your medication dose.
FDA Label Information
ACE Inhibitors, Angiotensin Receptor Blockers, or Beta-Blockers Clinical Impact: NSAIDs may diminish the antihypertensive effect of angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or beta-blockers (including propranolol).
Meloxicam Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Furosemide minor
- Aspirin minor
- Warfarin minor
Frequently Asked Questions
Can I take Meloxicam and Propranolol together?
This is a minor interaction. Your doctor should monitor your blood pressure closely. They may need to adjust your medication dose.
How serious is the interaction between Meloxicam and Propranolol?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Meloxicam and Propranolol interact?
Meloxicam can reduce the blood-pressure-lowering effects of propranolol. This makes your blood pressure medicine less effective.
Understanding the Meloxicam and Propranolol Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Meloxicam belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class and Propranolol belongs to the Non-Selective Beta-Blocker class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Meloxicam can reduce the blood-pressure-lowering effects of propranolol. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Meloxicam has 17 total documented interactions on file in this dataset, and Propranolol has 44. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor your blood pressure closely. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Meloxicam or Propranolol based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.