Meloxicam and Furosemide Interaction
Drug interaction information between Meloxicam and Furosemide.
Meloxicam and Furosemide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Meloxicam and Furosemide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This pain reliever can sometimes block the effects of water pills, making it harder for your body to get rid of extra salt.
FDA Label Information
Diuretics Clinical Impact: Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. However, studies with furosemide agents and meloxicam have not demonstrated a reduction in natriuretic effect. Furosemide single and multiple dose pharmacodynamics and pharmacokinetics are not affected by multiple doses of meloxicam.
Meloxicam Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Aspirin minor
- Propranolol minor
- Warfarin minor
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Meloxicam + Furosemide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Furosemide has 36 labeled pairs on file vs Meloxicam's 17. In the minor band specifically: Meloxicam has 15 (also Aspirin, Propranolol, Warfarin, Cyclosporine); Furosemide has 29 (also Methotrexate, Norepinephrine, Ethacrynic Acid, Indomethacin).
What mechanism field is on file for Meloxicam and Furosemide?
This pain reliever can sometimes block the effects of water pills, making it harder for your body to get rid of extra salt.
Furosemide carries more major-labeled pairs than Meloxicam
SPL source-record counts only. This page's band is minor · classes on file: Meloxicam (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Furosemide (Loop Diuretic).
Furosemide has 3 major-labeled pairs vs Meloxicam's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Meloxicam
- Aspirin
- Propranolol
- Warfarin
- Cyclosporine
3 major · 4 moderate · 29 minor · 36 total
- Other minor peers for Furosemide
- Methotrexate
- Norepinephrine
- Ethacrynic Acid
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.