Meloxicam and Diflunisal Interaction
Drug interaction information between Meloxicam and Diflunisal.
Meloxicam and Diflunisal have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Meloxicam and Diflunisal. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two drugs together increases the chance of serious stomach problems like bleeding or ulcers. Combining them does not provide any extra benefit for your pain or swelling.
FDA Label Information
NSAIDs and Salicylates Clinical Impact: Concomitant use of meloxicam with other NSAIDs or salicylates (e.g., diflunisal, salsalate) increases the risk of GI toxicity, with little or no increase in efficacy [see Warnings and Precautions ( 5.2 )].
Meloxicam Also Interacts With
- Methotrexate moderate
- Furosemide minor
- Aspirin minor
- Propranolol minor
- Warfarin minor
Diflunisal Also Interacts With
- Methotrexate moderate
- Cyclosporine moderate
- Celecoxib moderate
- Indomethacin moderate
- Mefenamic Acid moderate
Frequently Asked Questions
What SPL severity band is on file for Meloxicam + Diflunisal?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's moderate band?
Meloxicam and Diflunisal tie at 17 labeled pairs each. moderate-band counts: Meloxicam 2 alongside Methotrexate; Diflunisal 11 alongside Methotrexate, Cyclosporine, Celecoxib, Indomethacin.
What mechanism field is on file for Meloxicam and Diflunisal?
Using these two drugs together increases the chance of serious stomach problems like bleeding or ulcers. Combining them does not provide any extra benefit for your pain or swelling.
Meloxicam and Diflunisal · moderate-band peers
SPL source-record counts only. This page's band is moderate · classes on file: Meloxicam (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Diflunisal (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
0 major · 2 moderate · 15 minor · 17 total
- Other moderate peers for Meloxicam
- Methotrexate
0 major · 11 moderate · 6 minor · 17 total
- Other moderate peers for Diflunisal
- Methotrexate
- Cyclosporine
- Celecoxib
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.