Meloxicam and Warfarin Interaction
Drug interaction information between Meloxicam and Warfarin.
Meloxicam and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Meloxicam and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both meloxicam and warfarin interfere with blood clotting, which can lead to a higher risk of bleeding. When used together, their effects combine to make bleeding more likely.
FDA Label Information
Drugs that Interfere with Hemostasis Clinical Impact: Meloxicam and anticoagulants such as warfarin have a synergistic effect on bleeding. Intervention: Monitor patients with concomitant use of meloxicam with anticoagulants (e.g., warfarin), antiplatelet agents (e.g., aspirin), selective serotonin reuptake inhibitors (SSRIs), and serotonin norepinephrine reuptake inhibitors (SNRIs) for signs of bleeding [see Warnings and Precautions ( 5.12 )]. Drugs that Interfere with Hemostasis (e.g., warfarin, aspirin, SSRIs/SNRIs) : Monitor patients for bleeding who are concomitantly taking meloxicam...
Meloxicam Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Furosemide minor
- Aspirin minor
- Propranolol minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Meloxicam + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Meloxicam's 17. In the minor band specifically: Meloxicam has 15 (also Furosemide, Aspirin, Propranolol, Cyclosporine); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Meloxicam and Warfarin?
Both meloxicam and warfarin interfere with blood clotting, which can lead to a higher risk of bleeding. When used together, their effects combine to make bleeding more likely.
Warfarin carries more major-labeled pairs than Meloxicam
SPL source-record counts only. This page's band is minor · classes on file: Meloxicam (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Meloxicam's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Meloxicam
- Furosemide
- Aspirin
- Propranolol
- Cyclosporine
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.