Meloxicam and Methotrexate Interaction
Drug interaction information between Meloxicam and Methotrexate.
Meloxicam and Methotrexate have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Meloxicam and Methotrexate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Meloxicam can cause methotrexate to build up in your body to unsafe levels. This can lead to serious issues like low blood cell counts and kidney damage.
FDA Label Information
Methotrexate Clinical Impact: Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (e.g., neutropenia, thrombocytopenia, renal dysfunction). Intervention: During concomitant use of meloxicam and methotrexate, monitor patients for methotrexate toxicity.
Meloxicam Also Interacts With
- Diflunisal moderate
- Furosemide minor
- Aspirin minor
- Propranolol minor
- Warfarin minor
Methotrexate Also Interacts With
- Celecoxib moderate
- Diflunisal moderate
- Indomethacin moderate
- Mefenamic Acid moderate
- Misoprostol moderate
Frequently Asked Questions
What SPL severity band is on file for Meloxicam + Methotrexate?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methotrexate has 38 labeled pairs on file vs Meloxicam's 17. In the moderate band specifically: Meloxicam has 2 (also Diflunisal); Methotrexate has 12 (also Celecoxib, Diflunisal, Indomethacin, Mefenamic Acid).
What mechanism field is on file for Meloxicam and Methotrexate?
Meloxicam can cause methotrexate to build up in your body to unsafe levels. This can lead to serious issues like low blood cell counts and kidney damage.
Methotrexate's labeled portfolio outnumbers Meloxicam
SPL source-record counts only. This page's band is moderate · classes on file: Meloxicam (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Methotrexate (Disease-Modifying Antirheumatic Drug (DMARD)).
0 major · 12 moderate · 26 minor · 38 total
- Other moderate peers for Methotrexate
- Celecoxib
- Diflunisal
- Indomethacin
- Mefenamic Acid
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.