Levomilnacipran and Phenelzine Interaction
Drug interaction information between Levomilnacipran and Phenelzine.
Levomilnacipran and Phenelzine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Levomilnacipran and Phenelzine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs increase serotonin levels in the brain, which can lead to a dangerous buildup called serotonin syndrome.
FDA Label Information
Examples: selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact: Concomitant use of FETZIMA with other serotonergic drugs increases the risk of serotonin syndrome.
Levomilnacipran Also Interacts With
- Linezolid moderate
- Tranylcypromine moderate
- Selegiline moderate
- Buspirone minor
- Aspirin minor
Phenelzine Also Interacts With
- Sertraline moderate
- Fluoxetine moderate
- Citalopram moderate
- Venlafaxine moderate
- Fluvoxamine moderate
Frequently Asked Questions
What SPL severity band is on file for Levomilnacipran + Phenelzine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenelzine has 27 labeled pairs on file vs Levomilnacipran's 11. In the moderate band specifically: Levomilnacipran has 4 (also Linezolid, Tranylcypromine, Selegiline); Phenelzine has 11 (also Sertraline, Fluoxetine, Citalopram, Venlafaxine).
What mechanism field is on file for Levomilnacipran and Phenelzine?
Both drugs increase serotonin levels in the brain, which can lead to a dangerous buildup called serotonin syndrome.
Phenelzine's labeled portfolio outnumbers Levomilnacipran
SPL source-record counts only. This page's band is moderate · classes on file: Levomilnacipran (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)); Phenelzine (Monoamine Oxidase Inhibitor (MAOI)).
0 major · 4 moderate · 7 minor · 11 total
- Other moderate peers for Levomilnacipran
- Linezolid
- Tranylcypromine
- Selegiline
0 major · 11 moderate · 16 minor · 27 total
- Other moderate peers for Phenelzine
- Sertraline
- Fluoxetine
- Citalopram
- Venlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.