Levomilnacipran and Buspirone Interaction
Drug interaction information between Levomilnacipran and Buspirone.
Levomilnacipran and Buspirone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Levomilnacipran and Buspirone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines increase the levels of a brain chemical called serotonin. Taking them together can cause serotonin levels to become dangerously high.
FDA Label Information
Examples: other SNRIs, SSRIs, triptans, tricyclic antidepressants, opioids, lithium, buspirone, amphetamines, tryptophan, and St.
Levomilnacipran Also Interacts With
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
- Aspirin minor
Buspirone Also Interacts With
- Tranylcypromine moderate
- Ziprasidone moderate
- Citalopram minor
- Darunavir minor
- Desvenlafaxine minor
Frequently Asked Questions
What SPL severity band is on file for Levomilnacipran + Buspirone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Buspirone has 17 labeled pairs on file vs Levomilnacipran's 11. In the minor band specifically: Levomilnacipran has 7 (also Aspirin, Warfarin, Ketoconazole, Lithium); Buspirone has 15 (also Citalopram, Darunavir, Desvenlafaxine, Diltiazem).
What mechanism field is on file for Levomilnacipran and Buspirone?
Both of these medicines increase the levels of a brain chemical called serotonin. Taking them together can cause serotonin levels to become dangerously high.
Buspirone's labeled portfolio outnumbers Levomilnacipran
SPL source-record counts only. This page's band is minor · classes on file: Levomilnacipran (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)); Buspirone (Azapirone Anxiolytic).
0 major · 4 moderate · 7 minor · 11 total
- Other minor peers for Levomilnacipran
- Aspirin
- Warfarin
- Ketoconazole
- Lithium
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Buspirone
- Citalopram
- Darunavir
- Desvenlafaxine
- Diltiazem
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.