Levomilnacipran and Aspirin Interaction
Drug interaction information between Levomilnacipran and Aspirin.
Levomilnacipran and Aspirin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Levomilnacipran and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medicines can both interfere with how your blood forms clots. Using them together increases your risk of having problems with bleeding or bruising.
FDA Label Information
Examples: NSAIDs, aspirin, and warfarin Strong CYP3A4 Inhibitors Clinical Impact: Concomitant use of FETZIMA with strong CYP3A4 inhibitors increases levomilnacipran exposure [see Pharmacokinetics ( 12.3 )] .
Levomilnacipran Also Interacts With
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
- Buspirone minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Levomilnacipran + Aspirin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Levomilnacipran's 11. In the minor band specifically: Levomilnacipran has 7 (also Buspirone, Warfarin, Ketoconazole, Lithium); Aspirin has 32 (also Carisoprodol, Celecoxib, Colestipol, Diflunisal).
What mechanism field is on file for Levomilnacipran and Aspirin?
These medicines can both interfere with how your blood forms clots. Using them together increases your risk of having problems with bleeding or bruising.
Aspirin carries more major-labeled pairs than Levomilnacipran
SPL source-record counts only. This page's band is minor · classes on file: Levomilnacipran (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)); Aspirin (Antiplatelet / NSAID).
Aspirin has 3 major-labeled pairs vs Levomilnacipran's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 7 minor · 11 total
- Other minor peers for Levomilnacipran
- Buspirone
- Warfarin
- Ketoconazole
- Lithium
3 major · 12 moderate · 32 minor · 47 total
- Other minor peers for Aspirin
- Carisoprodol
- Celecoxib
- Colestipol
- Diflunisal
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.