What the FDA labels say about taking them together
Aspirin and levomilnacipran
Levomilnacipran's FDA label of April 30, 2024 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name levomilnacipran. The levomilnacipran label: “Concomitant use of FETZIMA with an antiplatelet or anticoagulant drug may potentiate the risk of bleeding. This may be due to the effect of FETZIMA on the release of serotonin by platelets.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the levomilnacipran FDA label on DailyMed (effective April 30, 2024, Allergan, Inc.).
What does the aspirin label say about levomilnacipran?
Aspirin's label (effective September 9, 2025) does not name levomilnacipran in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the levomilnacipran label say about aspirin?
Levomilnacipran label, drug interactionsClinical Impact: Concomitant use of FETZIMA with an antiplatelet or anticoagulant drug may potentiate the risk of bleeding. This may be due to the effect of FETZIMA on the release of serotonin by platelets. Intervention: Closely monitor for bleeding for patients receiving an antiplatelet or anticoagulant drug when FETZIMA is initiated or discontinued [see Warnings and Precautions ( 5.5 )]. NSAIDs, aspirin, and warfarin Strong CYP3A4 Inhibitors
Levomilnacipran label, warnings and precautionsIncreased Risk of Bleeding: Concomitant use of NSAIDs, aspirin, other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.5 ).
Source: FDA drug label (Fetzima), NDA204168 (Abbvie), as published by Allergan, Inc., effective April 30, 2024 (SPL set f371258d-91b3-4b6a-ac99-434a1964c3af), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Levomilnacipran | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $17.61 per unit 20-40 mg titration pak |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once