Levomilnacipran and Aspirin Interaction
Drug interaction information between Levomilnacipran and Aspirin.
Levomilnacipran and Aspirin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Levomilnacipran and Aspirin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These medicines can both interfere with how your blood forms clots. Using them together increases your risk of having problems with bleeding or bruising.
What To Do
Watch for signs of bleeding, such as easy bruising or dark stools. Your doctor may need to check your health more often if you take both.
FDA Label Information
Examples: NSAIDs, aspirin, and warfarin Strong CYP3A4 Inhibitors Clinical Impact: Concomitant use of FETZIMA with strong CYP3A4 inhibitors increases levomilnacipran exposure [see Pharmacokinetics ( 12.3 )] .
Levomilnacipran Also Interacts With
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
- Buspirone minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
Can I take Levomilnacipran and Aspirin together?
This is a minor interaction. Watch for signs of bleeding, such as easy bruising or dark stools. Your doctor may need to check your health more often if you take both.
How serious is the interaction between Levomilnacipran and Aspirin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Levomilnacipran and Aspirin interact?
These medicines can both interfere with how your blood forms clots. Using them together increases your risk of having problems with bleeding or bruising.
Understanding the Levomilnacipran and Aspirin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Levomilnacipran belongs to the Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) class and Aspirin belongs to the Antiplatelet / NSAID class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These medicines can both interfere with how your blood forms clots. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Levomilnacipran has 11 total documented interactions on file in this dataset, and Aspirin has 47. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Watch for signs of bleeding, such as easy bruising or dark stools. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Levomilnacipran or Aspirin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.