Levomilnacipran and Tranylcypromine Interaction
Drug interaction information between Levomilnacipran and Tranylcypromine.
Levomilnacipran and Tranylcypromine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Levomilnacipran and Tranylcypromine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs both raise serotonin levels, and using them at the same time can cause too much serotonin to build up in your body.
FDA Label Information
Examples: selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact: Concomitant use of FETZIMA with other serotonergic drugs increases the risk of serotonin syndrome.
Levomilnacipran Also Interacts With
- Linezolid moderate
- Phenelzine moderate
- Selegiline moderate
- Buspirone minor
- Aspirin minor
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
Frequently Asked Questions
What SPL severity band is on file for Levomilnacipran + Tranylcypromine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tranylcypromine has 42 labeled pairs on file vs Levomilnacipran's 11. In the moderate band specifically: Levomilnacipran has 4 (also Linezolid, Phenelzine, Selegiline); Tranylcypromine has 23 (also Buspirone, Cyclobenzaprine, Carbamazepine, Lithium).
What mechanism field is on file for Levomilnacipran and Tranylcypromine?
These drugs both raise serotonin levels, and using them at the same time can cause too much serotonin to build up in your body.
Tranylcypromine carries more major-labeled pairs than Levomilnacipran
SPL source-record counts only. This page's band is moderate · classes on file: Levomilnacipran (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)); Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)).
Tranylcypromine has 7 major-labeled pairs vs Levomilnacipran's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 7 minor · 11 total
- Other moderate peers for Levomilnacipran
- Linezolid
- Phenelzine
- Selegiline
7 major · 23 moderate · 12 minor · 42 total
- Other moderate peers for Tranylcypromine
- Buspirone
- Cyclobenzaprine
- Carbamazepine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.