Linagliptin and Rifampin Interaction
Drug interaction information between Linagliptin and Rifampin.
Linagliptin and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Linagliptin and Rifampin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Rifampin speeds up how fast your body breaks down linagliptin, which lowers the amount of medicine in your system. This can make the diabetes drug less effective at controlling your blood sugar.
What To Do
Your doctor may need to choose a different medication or monitor your blood sugar more closely while you are taking rifampin.
FDA Label Information
Inducers of P-glycoprotein or CYP3A4 Enzymes Clinical Impact Rifampin decreased linagliptin exposure, suggesting that the efficacy of linagliptin may be reduced when administered in combination with a strong P-gp or CYP3A4 inducer. ( 7 ) Strong P-glycoprotein/CYP3A4 Inducer: Efficacy may be reduced when administered in combination (e.g., rifampin).
Linagliptin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Topiramate minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
Can I take Linagliptin and Rifampin together?
This is a minor interaction. Your doctor may need to choose a different medication or monitor your blood sugar more closely while you are taking rifampin.
How serious is the interaction between Linagliptin and Rifampin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Linagliptin and Rifampin interact?
Rifampin speeds up how fast your body breaks down linagliptin, which lowers the amount of medicine in your system. This can make the diabetes drug less effective at controlling your blood sugar.
Understanding the Linagliptin and Rifampin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Linagliptin belongs to the DPP-4 Inhibitor class and Rifampin belongs to the Rifamycin Antibiotic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Rifampin speeds up how fast your body breaks down linagliptin, which lowers the amount of medicine in your system. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Linagliptin has 9 total documented interactions on file in this dataset, and Rifampin has 137. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to choose a different medication or monitor your blood sugar more closely while you are taking rifampin. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Linagliptin or Rifampin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.