What the FDA labels say about taking them together
Linagliptin and rifampin
Linagliptin's FDA label of March 21, 2025 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name linagliptin. The linagliptin label: “DRUG INTERACTIONS Strong P-glycoprotein/CYP3A4 inducer: The efficacy of TRADJENTA may be reduced when administered in combination (e.g., with rifampin).”
Check it at the source: the linagliptin FDA label on DailyMed (effective March 21, 2025, Boehringer Ingelheim Pharmaceuticals, Inc.); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the linagliptin label say about rifampin?
Linagliptin label, drug interactionsDRUG INTERACTIONS Strong P-glycoprotein/CYP3A4 inducer: The efficacy of TRADJENTA may be reduced when administered in combination (e.g., with rifampin).
Source: FDA drug label (Tradjenta), Boehringer Ingelheim Pharmaceuticals, Inc., effective March 21, 2025 (SPL set c797ea5c-cab7-494b-9044-27eba0cfe40f), via openFDA; the full label on DailyMed
What does the rifampin label say about linagliptin?
Rifampin's label (effective February 11, 2026) does not name linagliptin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Linagliptin | Rifampin | |
|---|---|---|
| Labeled for | Type 2 diabetes | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $16.80 per tablet 5 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once