Linagliptin and Topiramate Interaction
Drug interaction information between Linagliptin and Topiramate.
Linagliptin and Topiramate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Linagliptin and Topiramate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Topiramate can lower the level of bicarbonate in your blood, which makes your blood more acidic. This increases the risk of a serious condition called metabolic acidosis when taken with this diabetes medication.
Linagliptin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Rifampin minor
Topiramate Also Interacts With
- Zonisamide moderate
- Alogliptin moderate
- Ertugliflozin moderate
- Hydrochlorothiazide minor
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Linagliptin + Topiramate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Topiramate has 30 labeled pairs on file vs Linagliptin's 9. In the minor band specifically: Linagliptin has 5 (also Rifampin, Phenytoin, Zonisamide, Empagliflozin/Linagliptin); Topiramate has 27 (also Hydrochlorothiazide, Amitriptyline, Pioglitazone, Carbamazepine).
What mechanism field is on file for Linagliptin and Topiramate?
Topiramate can lower the level of bicarbonate in your blood, which makes your blood more acidic. This increases the risk of a serious condition called metabolic acidosis when taken with this diabetes medication.
Topiramate's labeled portfolio outnumbers Linagliptin
SPL source-record counts only. This page's band is minor · classes on file: Linagliptin (DPP-4 Inhibitor); Topiramate (Anticonvulsant).
0 major · 4 moderate · 5 minor · 9 total
- Other minor peers for Linagliptin
- Rifampin
- Phenytoin
- Zonisamide
- Empagliflozin/Linagliptin
0 major · 3 moderate · 27 minor · 30 total
- Other minor peers for Topiramate
- Hydrochlorothiazide
- Amitriptyline
- Pioglitazone
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.