Linagliptin and Empagliflozin/Linagliptin Interaction
Drug interaction information between Linagliptin and Empagliflozin/Linagliptin.
Linagliptin and Empagliflozin/Linagliptin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Linagliptin and Empagliflozin/Linagliptin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Some drugs make your body process linagliptin too quickly, which can make the medication less effective at lowering your blood sugar.
FDA Label Information
Inducers of P-glycoprotein or CYP3A4 Enzymes Clinical Impact Rifampin decreased linagliptin exposure, suggesting that the efficacy of linagliptin may be reduced when administered in combination with a strong P-gp or CYP3A4 inducer. Intervention Use of alternative treatments is strongly recommended when linagliptin is to be administered with a strong P-gp or CYP3A4 inducer.
Linagliptin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Topiramate minor
Empagliflozin/Linagliptin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Empagliflozin minor
Frequently Asked Questions
What SPL severity band is on file for Linagliptin + Empagliflozin/Linagliptin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Empagliflozin/Linagliptin has 11 labeled pairs on file vs Linagliptin's 9. In the minor band specifically: Linagliptin has 5 (also Topiramate, Rifampin, Phenytoin, Zonisamide); Empagliflozin/Linagliptin has 7 (also Empagliflozin, Topiramate, Lithium, Rifampin).
What mechanism field is on file for Linagliptin and Empagliflozin/Linagliptin?
Some drugs make your body process linagliptin too quickly, which can make the medication less effective at lowering your blood sugar.
Empagliflozin/Linagliptin's labeled portfolio outnumbers Linagliptin
SPL source-record counts only. This page's band is minor · classes on file: Linagliptin (DPP-4 Inhibitor); Empagliflozin/Linagliptin (SGLT2 / DPP-4 Combination).
0 major · 4 moderate · 5 minor · 9 total
- Other minor peers for Linagliptin
- Topiramate
- Rifampin
- Phenytoin
- Zonisamide
0 major · 4 moderate · 7 minor · 11 total
- Other minor peers for Empagliflozin/Linagliptin
- Empagliflozin
- Topiramate
- Lithium
- Rifampin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.