Lidocaine Topical and Nitroglycerin Interaction
Drug interaction information between Lidocaine Topical and Nitroglycerin.
Lidocaine Topical and Nitroglycerin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Lidocaine Topical and Nitroglycerin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines can cause a blood condition that stops oxygen from reaching your body's tissues. Using them together increases the chance of this serious side effect.
FDA Label Information
Drugs That May Cause Methemoglobinemia When Used with LIDODERM Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia : Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea,...
Lidocaine Topical Also Interacts With
- Acetaminophen moderate
- Nitrofurantoin moderate
- Valproate moderate
- Chloroquine moderate
- Mexiletine moderate
Nitroglycerin Also Interacts With
- Dapsone Topical moderate
- Aspirin minor
- Sildenafil minor
- Tadalafil minor
- Heparin minor
Frequently Asked Questions
What SPL severity band is on file for Lidocaine Topical + Nitroglycerin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lidocaine Topical has 10 labeled pairs on file vs Nitroglycerin's 8. In the moderate band specifically: Lidocaine Topical has 10 (also Acetaminophen, Nitrofurantoin, Valproate, Chloroquine); Nitroglycerin has 2 (also Dapsone Topical).
What mechanism field is on file for Lidocaine Topical and Nitroglycerin?
Both of these medicines can cause a blood condition that stops oxygen from reaching your body's tissues. Using them together increases the chance of this serious side effect.
Lidocaine Topical's labeled portfolio outnumbers Nitroglycerin
SPL source-record counts only. This page's band is moderate · classes on file: Lidocaine Topical (Topical Anesthetic); Nitroglycerin (Nitrate Vasodilator).
0 major · 10 moderate · 0 minor · 10 total
- Other moderate peers for Lidocaine Topical
- Acetaminophen
- Nitrofurantoin
- Valproate
- Chloroquine
0 major · 2 moderate · 6 minor · 8 total
- Other moderate peers for Nitroglycerin
- Dapsone Topical
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.