darunavir vs ivabradine
Side-by-side comparison of darunavir and ivabradine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Cardiac Disorders : ranolazine, ivabradine ↑ ranolazine ↑ ivabradine Co-administration is contraindicated due to potential for serious and/or life-threatening reactions.
Recommendation: Avoid taking these two drugs at the same time to prevent serious health risks.
Prezista
Corlanor
Darunavir is a medicine used to treat HIV. It belongs to a class of drugs called protease inhibitors and must be taken with ritonavir.
Ivabradine (Corlanor) is a medicine that helps lower the risk of needing to go to the hospital for worsening heart failure. It works by slowing down your heart rate.
Darunavir is used to treat HIV-1 infection in adults and children 3 years and older. It must be taken with ritonavir and other HIV medicines. Darunavir helps to lower the amount of HIV in your body.
Ivabradine is used to lower the chance of hospitalization if your heart failure gets worse. It is for adults who have stable, long-term heart failure and a weak heart (left ventricular ejection fraction ≤ 35%). You must also have a resting heart rate of 70 beats per minute or higher and are either taking the highest dose of beta-blockers you can handle or cannot take beta-blockers at all.
Darunavir is a protease inhibitor. It works by blocking an enzyme called protease that HIV needs to make copies of itself. This helps to slow down the spread of HIV in your body.
Ivabradine works by blocking certain channels in your heart called HCN channels. These channels control your heart's natural pacemaker. By blocking these channels, ivabradine slows down your heart rate.
- • Diarrhea
- • Nausea
- • Rash
- • Headache
- • Abdominal pain
- • Slow heart rate
- • High blood pressure
- • Irregular heartbeat (atrial fibrillation)
- • Seeing bright flashes of light
- Baby exposed to drug during pregnancy 1,150
- Interaction between medicines 981
- Pain 889
- Emotional upset 812
- Worry 811
- Shortness of breath 459
- Low blood pressure 413
- Feeling lightheaded or unsteady 350
- Heart failure 324
- Feeling very tired 317
Darunavir can cause liver problems. Your doctor should check your liver before you start taking darunavir and during treatment. Tell your doctor right away if you have any signs of liver problems, such as yellowing of the skin or eyes.
Ivabradine can harm an unborn baby. If you are a woman who could get pregnant, use effective birth control while taking this medicine. This medicine can also cause a very slow heart rate. Your doctor will monitor your heart rate and adjust your dose as needed.
Tell your doctor if you are pregnant or plan to become pregnant. The recommended dose during pregnancy is 600 mg twice daily with ritonavir 100mg and food. Women with HIV should not breastfeed because HIV can be passed to the baby through breast milk.
Ivabradine can cause harm to an unborn baby. Do not take this medicine if you are pregnant or planning to become pregnant. It is not recommended to breastfeed while taking ivabradine.
How to Read This darunavir vs ivabradine Comparison
darunavir is classified in the HIV Protease Inhibitor drug class, while ivabradine sits within the HCN Channel Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, darunavir has 4,643 submissions while ivabradine has 1,863. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to darunavir prevents your body from clearing ivabradine, which causes the drug to build up to unsafe levels. this increase can lead to severe or life-threatening reactions.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between darunavir and ivabradine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.