Isotretinoin and Estradiol Interaction
Drug interaction information between Isotretinoin and Estradiol.
Isotretinoin and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Isotretinoin and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Studies show that isotretinoin does not change the levels of estradiol in your body. It does not interfere with how this hormone is processed.
FDA Label Information
Norethindrone/ethinyl estradiol: In a study of 31 premenopausal female patients with severe recalcitrant nodular acne receiving OrthoNovum ® 7/7/7 Tablets as an oral contraceptive agent, isotretinoin capsules at the recommended dose of 1 mg/kg/day, did not induce clinically relevant changes in the pharmacokinetics of ethinyl estradiol and norethindrone and in the serum levels of progesterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Isotretinoin Also Interacts With
- Progesterone major
- Retinol moderate
- Norethindrone minor
- Phenytoin minor
- Minocycline minor
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Isotretinoin + Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Isotretinoin's 7. In the minor band specifically: Isotretinoin has 5 (also Norethindrone, Phenytoin, Minocycline, Prenatal Multivitamin); Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine).
What mechanism field is on file for Isotretinoin and Estradiol?
Studies show that isotretinoin does not change the levels of estradiol in your body. It does not interfere with how this hormone is processed.
Estradiol's labeled portfolio outnumbers Isotretinoin
SPL source-record counts only. This page's band is minor · classes on file: Isotretinoin (Systemic Retinoid); Estradiol (Estrogen Hormone).
1 major · 1 moderate · 5 minor · 7 total
- Other minor peers for Isotretinoin
- Norethindrone
- Phenytoin
- Minocycline
- Prenatal Multivitamin
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.