What the FDA labels say about taking them together
Isotretinoin and progesterone
Isotretinoin's FDA label (Isotretinoin) of January 10, 2024 names progesterone in its drug interactions section; the progesterone labels PlainMeds reads (3) do not name isotretinoin. The isotretinoin label: “… pharmacokinetics of ethinyl estradiol and norethindrone and in the serum levels of progesterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH).”
Check it at the source: the isotretinoin FDA label on DailyMed (effective August 19, 2026, Sun Pharmaceutical Industries, Inc.); the progesterone FDA label on DailyMed (effective July 23, 2026, Acertis Pharmaceuticals, LLC).
What does the isotretinoin label say about progesterone?
Isotretinoin label (Sun Pharmaceutical Industries, Inc., January 10, 2024), drug interactionsIn a trial of 31 premenopausal female patients with severe recalcitrant nodular acne receiving norethindrone and ethinyl estradiol as an oral contraceptive agent, isotretinoin capsules within the recommended dosage, did not induce clinically relevant changes in the pharmacokinetics of ethinyl estradiol and norethindrone and in the serum levels of progesterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Source: FDA drug label (Isotretinoin, NDA021951), Sun Pharmaceutical Industries, Inc., effective January 10, 2024 (SPL set b44200ba-6672-4ea7-b151-7caec3f53c9c), via openFDA
Source: FDA drug label (Absorica LD), Sun Pharmaceutical Industries, Inc., effective August 19, 2026 (SPL set 3ef0cff8-19c1-4441-b780-fca6c7ee1615), via openFDA; the full label on DailyMed
What does the progesterone label say about isotretinoin?
Progesterone's label (effective July 23, 2026) and its 2 other brand-application labels do not name isotretinoin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Prometrium), Acertis Pharmaceuticals, LLC, effective July 23, 2026 (SPL set 1cf237ff-c4f8-4faa-a7aa-77599c856889), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Isotretinoin | Progesterone | |
|---|---|---|
| Labeled for | Acne | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $11.94 per capsule 10 mg capsule | $0.229 per capsule 100 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once