Isotretinoin and Progesterone Interaction
Drug interaction information between Isotretinoin and Progesterone.
Isotretinoin and Progesterone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Isotretinoin and Progesterone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This drug can interfere with 'mini-pills' that only contain progesterone, making them less reliable for preventing pregnancy.
FDA Label Information
Micro-dosed Progesterone Preparations: Micro-dosed progesterone preparations ("minipills" that do not contain an estrogen) may be an inadequate method of contraception during isotretinoin capsules therapy. Norethindrone/ethinyl estradiol: In a study of 31 premenopausal female patients with severe recalcitrant nodular acne receiving OrthoNovum ® 7/7/7 Tablets as an oral contraceptive agent, isotretinoin capsules at the recommended dose of 1 mg/kg/day, did not induce clinically relevant changes in the pharmacokinetics of ethinyl estradiol and norethindrone and in the serum levels of...
Isotretinoin Also Interacts With
- Retinol moderate
- Estradiol minor
- Norethindrone minor
- Phenytoin minor
- Minocycline minor
Progesterone Also Interacts With
- Theophylline major
- Amoxicillin minor
- Amoxicillin/Clavulanate minor
- Medroxyprogesterone minor
- Phenobarbital minor
Frequently Asked Questions
What SPL severity band is on file for Isotretinoin + Progesterone?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's major band?
Isotretinoin and Progesterone tie at 7 labeled pairs each. major-band counts: Isotretinoin 1; Progesterone 2 alongside Theophylline.
What mechanism field is on file for Isotretinoin and Progesterone?
This drug can interfere with 'mini-pills' that only contain progesterone, making them less reliable for preventing pregnancy.
Progesterone carries more major-labeled pairs than Isotretinoin
SPL source-record counts only. This page's band is major · classes on file: Isotretinoin (Systemic Retinoid); Progesterone (Progestogen Hormone).
Progesterone has 2 major-labeled pairs vs Isotretinoin's 1.
1 major · 1 moderate · 5 minor · 7 total
Isotretinoin has no other major-band peer in this dataset besides Progesterone.
2 major · 0 moderate · 5 minor · 7 total
- Other major peers for Progesterone
- Theophylline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.