Isotretinoin and Norethindrone Interaction
Drug interaction information between Isotretinoin and Norethindrone.
Isotretinoin and Norethindrone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Isotretinoin and Norethindrone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Isotretinoin does not affect the amount of norethindrone in your blood or how well it works. It does not seem to change the effectiveness of this hormone.
FDA Label Information
Norethindrone/ethinyl estradiol: In a study of 31 premenopausal female patients with severe recalcitrant nodular acne receiving OrthoNovum ® 7/7/7 Tablets as an oral contraceptive agent, isotretinoin capsules at the recommended dose of 1 mg/kg/day, did not induce clinically relevant changes in the pharmacokinetics of ethinyl estradiol and norethindrone and in the serum levels of progesterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Isotretinoin Also Interacts With
- Progesterone major
- Retinol moderate
- Estradiol minor
- Phenytoin minor
- Minocycline minor
Norethindrone Also Interacts With
- Voriconazole major
- Atorvastatin minor
- Colchicine minor
- Colesevelam minor
- Darunavir minor
Frequently Asked Questions
What SPL severity band is on file for Isotretinoin + Norethindrone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Norethindrone has 10 labeled pairs on file vs Isotretinoin's 7. In the minor band specifically: Isotretinoin has 5 (also Estradiol, Phenytoin, Minocycline, Prenatal Multivitamin); Norethindrone has 9 (also Atorvastatin, Colchicine, Colesevelam, Darunavir).
What mechanism field is on file for Isotretinoin and Norethindrone?
Isotretinoin does not affect the amount of norethindrone in your blood or how well it works. It does not seem to change the effectiveness of this hormone.
Norethindrone's labeled portfolio outnumbers Isotretinoin
SPL source-record counts only. This page's band is minor · classes on file: Isotretinoin (Systemic Retinoid); Norethindrone (Progestin-Only Oral Contraceptive).
1 major · 1 moderate · 5 minor · 7 total
- Other minor peers for Isotretinoin
- Estradiol
- Phenytoin
- Minocycline
- Prenatal Multivitamin
1 major · 0 moderate · 9 minor · 10 total
- Other minor peers for Norethindrone
- Atorvastatin
- Colchicine
- Colesevelam
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.