Isotretinoin and Prenatal Multivitamin Interaction
Drug interaction information between Isotretinoin and Prenatal Multivitamin.
Isotretinoin and Prenatal Multivitamin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Isotretinoin and Prenatal Multivitamin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking this medicine can lead to lower levels of folate in your body. It changes how your body maintains this vitamin in your blood.
FDA Label Information
• Isotretinoin: Reduced folate levels have occurred in some patients taking isotretinoin.
Isotretinoin Also Interacts With
- Progesterone major
- Retinol moderate
- Estradiol minor
- Norethindrone minor
- Phenytoin minor
Prenatal Multivitamin Also Interacts With
- Trimethoprim moderate
- Phenytoin moderate
- Metformin minor
- Fluoxetine minor
- Ibuprofen minor
Frequently Asked Questions
What SPL severity band is on file for Isotretinoin + Prenatal Multivitamin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Prenatal Multivitamin has 23 labeled pairs on file vs Isotretinoin's 7. In the minor band specifically: Isotretinoin has 5 (also Estradiol, Norethindrone, Phenytoin, Minocycline); Prenatal Multivitamin has 21 (also Metformin, Fluoxetine, Ibuprofen, Potassium Chloride).
What mechanism field is on file for Isotretinoin and Prenatal Multivitamin?
Taking this medicine can lead to lower levels of folate in your body. It changes how your body maintains this vitamin in your blood.
Isotretinoin carries more major-labeled pairs than Prenatal Multivitamin
SPL source-record counts only. This page's band is minor · classes on file: Isotretinoin (Systemic Retinoid); Prenatal Multivitamin (Prenatal Vitamin).
Isotretinoin has 1 major-labeled pair vs Prenatal Multivitamin's 0. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 5 minor · 7 total
- Other minor peers for Isotretinoin
- Estradiol
- Norethindrone
- Phenytoin
- Minocycline
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Prenatal Multivitamin
- Metformin
- Fluoxetine
- Ibuprofen
- Potassium Chloride
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.