Imipramine and Atropine Interaction
Drug interaction information between Imipramine and Atropine.
Imipramine and Atropine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Imipramine and Atropine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs have similar drying effects on the body, which can lead to more severe side effects like severe constipation or a blocked bowel.
FDA Label Information
In occasional susceptible patients or in those receiving anticholinergic drugs (including antiparkinsonism agents) in addition, the atropine-like effects may become more pronounced (e.g., paralytic ileus).
Imipramine Also Interacts With
- Epinephrine moderate
- Norepinephrine moderate
- Zolpidem moderate
- Sertraline minor
- Paroxetine minor
Atropine Also Interacts With
- Mexiletine minor
- Metoclopramide minor
- Midazolam minor
- Nabilone minor
- Pramlintide minor
Frequently Asked Questions
What SPL severity band is on file for Imipramine + Atropine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Imipramine has 20 labeled pairs on file vs Atropine's 6. In the minor band specifically: Imipramine has 17 (also Sertraline, Paroxetine, Flecainide, Propafenone); Atropine has 6 (also Mexiletine, Metoclopramide, Midazolam, Nabilone).
What mechanism field is on file for Imipramine and Atropine?
Both drugs have similar drying effects on the body, which can lead to more severe side effects like severe constipation or a blocked bowel.
Imipramine's labeled portfolio outnumbers Atropine
SPL source-record counts only. This page's band is minor · classes on file: Imipramine (Tricyclic Antidepressant (TCA)); Atropine (Anticholinergic).
0 major · 3 moderate · 17 minor · 20 total
- Other minor peers for Imipramine
- Sertraline
- Paroxetine
- Flecainide
- Propafenone
0 major · 0 moderate · 6 minor · 6 total
- Other minor peers for Atropine
- Mexiletine
- Metoclopramide
- Midazolam
- Nabilone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.