hydrochlorothiazide/lisinopril vs propranolol
Side-by-side comparison of hydrochlorothiazide/lisinopril and propranolol. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
No meaningful clinically important pharmacokinetic interactions occurred when lisinopril was used concomitantly with propranolol, digoxin, or hydrochlorothiazide.
Recommendation: No special precautions are usually needed when taking these medications together.
Zestoretic
Inderal
Zestoretic is a drug that combines lisinopril and hydrochlorothiazide. It is used to treat high blood pressure.
Propranolol is a medicine that can help with high blood pressure, chest pain, and other conditions. It works by blocking the effects of certain natural chemicals in your body, like adrenaline, that affect the heart and blood vessels.
Zestoretic is used to treat high blood pressure. Lowering blood pressure reduces the risk of heart problems and strokes. Controlling high blood pressure should also include managing cholesterol, diabetes, and quitting smoking. Many people need more than one medicine to control their blood pressure.
Propranolol tablets can treat high blood pressure. It can be used alone or with other medicines. Propranolol can also help with chest pain (angina), control fast heart rate with atrial fibrillation, improve survival after a heart attack, prevent migraine headaches, and reduce tremors. It can also help with symptoms of some tumors.
Zestoretic contains two medicines. Lisinopril is an ACE inhibitor that widens blood vessels. Hydrochlorothiazide is a diuretic that helps your body get rid of extra salt and water, which also lowers blood pressure.
Propranolol is a beta-blocker. It works by blocking the effects of adrenaline on your heart and blood vessels. This helps to slow down your heart rate and lower your blood pressure.
- • Dizziness
- • Headache
- • Cough
- • Feeling tired
- • Tiredness
- • Dizziness
- • Nausea
- • Vomiting
- • Diarrhea
- Feeling tired 10,013
- Feeling sick to your stomach 9,706
- Loose stools 8,311
- Discomfort 7,665
- Difficulty breathing 7,584
- Feeling sick to your stomach 4,279
- Pain in your head 3,784
- Feeling very tired 3,752
- Loose, watery stools 3,121
- Feeling lightheaded or unsteady 3,102
This drug can cause serious harm or death to an unborn baby. Stop taking Zestoretic as soon as you find out you are pregnant.
Propranolol is contraindicated in people with cardiogenic shock, very slow heart rate, asthma, or those who are allergic to it.
Do not take Zestoretic if you are pregnant. It can harm your unborn baby. Talk to your doctor about other blood pressure medicines if you are breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. Propranolol may affect your baby. Talk to your doctor about the risks and benefits of taking propranolol during pregnancy or while breastfeeding.
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How to Read This hydrochlorothiazide/lisinopril vs propranolol Comparison
hydrochlorothiazide/lisinopril is classified in the Thiazide Diuretic / ACE Inhibitor Combination drug class, while propranolol sits within the Non-Selective Beta-Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, hydrochlorothiazide/lisinopril has 43,279 submissions while propranolol has 18,038. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these drugs do not interfere with how each other is absorbed or processed by the body.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between hydrochlorothiazide/lisinopril and propranolol - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.