Glipizide and Posaconazole Interaction
Drug interaction information between Glipizide and Posaconazole.
Glipizide and Posaconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glipizide and Posaconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs together can interfere with how your body manages blood sugar, potentially causing your levels to drop too low.
FDA Label Information
7.14 Glipizide Although no dosage adjustment of glipizide is required, it is recommended to monitor glucose concentrations when posaconazole and glipizide are concomitantly used.
Glipizide Also Interacts With
- Fluconazole minor
- Colesevelam minor
- Probenecid minor
- Phenytoin minor
- Lovastatin minor
Posaconazole Also Interacts With
- Esomeprazole major
- Digoxin major
- Cimetidine major
- Metoclopramide major
- Phenytoin major
Frequently Asked Questions
What SPL severity band is on file for Glipizide + Posaconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Posaconazole has 27 labeled pairs on file vs Glipizide's 8. In the minor band specifically: Glipizide has 8 (also Fluconazole, Colesevelam, Probenecid, Phenytoin); Posaconazole has 17 (also Alprazolam, Diltiazem, Nifedipine, Verapamil).
What mechanism field is on file for Glipizide and Posaconazole?
Taking these two drugs together can interfere with how your body manages blood sugar, potentially causing your levels to drop too low.
Posaconazole carries more major-labeled pairs than Glipizide
SPL source-record counts only. This page's band is minor · classes on file: Glipizide (Sulfonylurea); Posaconazole (Azole Antifungal).
Posaconazole has 5 major-labeled pairs vs Glipizide's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Glipizide
- Fluconazole
- Colesevelam
- Probenecid
- Phenytoin
5 major · 5 moderate · 17 minor · 27 total
- Other minor peers for Posaconazole
- Alprazolam
- Diltiazem
- Nifedipine
- Verapamil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.