fluconazole vs glipizide
Side-by-side comparison of fluconazole and glipizide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
The effect of concomitant administration of DIFLUCAN ® (fluconazole) and glipizide has been demonstrated in a placebo-controlled crossover study in normal volunteers. All subjects received glipizide alone and following treatment with 100 mg of DIFLUCAN as a single daily oral dose for 7 days. The mean percentage increase in the glipizide AUC after fluconazole administration was 56.9% (range: 35 to 81).
Recommendation: Your doctor may need to lower your glipizide dose while you are taking fluconazole. Be sure to check your blood sugar levels regularly.
Diflucan
Glucotrol
Fluconazole is an antifungal medicine. It is used to treat infections caused by fungus.
Glipizide is a medicine that helps lower blood sugar in adults with type 2 diabetes. It works along with diet and exercise.
Fluconazole treats vaginal yeast infections. It also treats yeast infections in the mouth and esophagus. Fluconazole can also treat urinary tract infections, peritonitis, systemic Candida infections, and pneumonia. It can also treat cryptococcal meningitis. Fluconazole can also prevent candidiasis in patients undergoing bone marrow transplantation.
Glipizide is used to improve blood sugar control in adults who have type 2 diabetes. It is meant to be used in addition to diet and exercise. This medicine helps your body use insulin better and lowers blood sugar levels.
Fluconazole works by stopping the growth of fungi. It blocks the fungus from producing a substance it needs to grow. This helps to clear up the infection.
Glipizide belongs to a class of drugs called sulfonylureas. It works by helping your pancreas release more insulin. Insulin then helps your body use sugar from the food you eat.
- • Headache
- • Nausea
- • Abdominal pain
- • Nausea
- • Diarrhea
- • Skin rash
- • Dizziness
- • Drowsiness
- Fever 4,121
- Feeling sick to your stomach 3,695
- Loose stools 3,536
- Feeling tired 3,152
- Discomfort 3,121
- High blood sugar 6,673
- Feeling sick to your stomach 4,442
- Loose, watery stools 3,266
- Feeling tired 2,999
- Weight loss 2,811
Coadministration of other drugs known to prolong the QT interval and which are metabolized via the enzyme CYP3A4 such as erythromycin, pimozide, and quinidine are contraindicated in patients receiving fluconazole.
Glipizide can cause low blood sugar (hypoglycemia). Watch for symptoms like shakiness, sweating, confusion, and rapid heartbeat. If you have very low blood sugar, get medical help right away. Certain drugs can increase the risk of low blood sugar. Tell your doctor about all the medicines you take.
Tell your doctor if you are pregnant or plan to become pregnant. Fluconazole may not be safe for your baby. Talk to your doctor about breastfeeding while taking fluconazole.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if glipizide will harm your unborn baby. Talk to your doctor about the best way to control your blood sugar during pregnancy. It is not recommended to breastfeed while taking this medication.
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How to Read This fluconazole vs glipizide Comparison
fluconazole is classified in the Azole Antifungal drug class, while glipizide sits within the Sulfonylurea class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluconazole has 17,625 submissions while glipizide has 20,191. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to fluconazole slows down the way your body breaks down glipizide, which causes the medicine to build up in your blood. this can lead to a dangerous drop in blood sugar levels.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between fluconazole and glipizide - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.