Colesevelam and Olmesartan Interaction
Drug interaction information between Colesevelam and Olmesartan.
Colesevelam and Olmesartan have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Colesevelam and Olmesartan. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Colesevelam can stick to olmesartan in your stomach, which prevents your body from absorbing the blood pressure medicine correctly.
FDA Label Information
7 DRUG INTERACTIONS Lithium: Risk of lithium toxicity ( 7.2 ) Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic and antihypotensive effects; increased risk of renal toxicity ( 7.3 ) Dual inhibition of the renin-angiotensin system: Increased risk of renal impairment, hypotension, and hyperkalemia ( 7.4 ) Colesevelam hydrochloride: Consider administering olmesartan at least 4 hours before colesevelam hydrochloride dose ( 7.5 ) Antidiabetic drugs: Dosage adjustment may be required ( 7.6 ) Cholestyramine and colestipol: Reduced absorption of thiazides ( 7.6 ) 7.1...
Colesevelam Also Interacts With
- Metformin minor
- Warfarin minor
- Norethindrone minor
- Cyclosporine minor
- Glyburide minor
Olmesartan Also Interacts With
- Aliskiren major
- Hydrochlorothiazide moderate
- Lithium moderate
- Cholestyramine moderate
- Colestipol moderate
Frequently Asked Questions
What SPL severity band is on file for Colesevelam + Olmesartan?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Colesevelam has 15 labeled pairs on file vs Olmesartan's 7. In the moderate band specifically: Colesevelam has 1; Olmesartan has 6 (also Hydrochlorothiazide, Lithium, Cholestyramine, Colestipol).
What mechanism field is on file for Colesevelam and Olmesartan?
Colesevelam can stick to olmesartan in your stomach, which prevents your body from absorbing the blood pressure medicine correctly.
Olmesartan carries more major-labeled pairs than Colesevelam
SPL source-record counts only. This page's band is moderate · classes on file: Colesevelam (Bile Acid Sequestrant (Diabetes)); Olmesartan (Angiotensin II Receptor Blocker (ARB)).
Olmesartan has 1 major-labeled pair vs Colesevelam's 0. This page itself is in the moderate band, not the major band.
0 major · 1 moderate · 14 minor · 15 total
Colesevelam has no other moderate-band peer in this dataset besides Olmesartan.
1 major · 6 moderate · 0 minor · 7 total
- Other moderate peers for Olmesartan
- Hydrochlorothiazide
- Lithium
- Cholestyramine
- Colestipol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.