Colesevelam and Metformin Interaction
Drug interaction information between Colesevelam and Metformin.
Colesevelam and Metformin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Colesevelam and Metformin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Colesevelam can raise the levels of metformin in your body by increasing how much of the drug you are exposed to.
FDA Label Information
Concomitant use with colesevelam hydrochloride may increase the exposure of the following drugs: Metformin extended release. 7.2 Colesevelam Hydrochloride Drug Interactions that Increase the Exposure of the Concomitant Medication Table 5 Colesevelam Hydrochloride Drug Interactions that Increase the Exposure of the Concomitant Medication Metformin Extended Release (ER) Clinical Impact: In vivo drug interactions studies showed an increase in metformin extended release (ER) when coadministered with colesevelam hydrochloride [see Clinical Pharmacology (12.3) ].
Colesevelam Also Interacts With
- Olmesartan moderate
- Warfarin minor
- Norethindrone minor
- Cyclosporine minor
- Glyburide minor
Metformin Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir moderate
- Dolutegravir/Lamivudine moderate
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
Frequently Asked Questions
What SPL severity band is on file for Colesevelam + Metformin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metformin has 27 labeled pairs on file vs Colesevelam's 15. In the minor band specifically: Colesevelam has 14 (also Warfarin, Norethindrone, Cyclosporine, Glyburide); Metformin has 17 (also Topiramate, Dolutegravir, Ranolazine, Cimetidine).
What mechanism field is on file for Colesevelam and Metformin?
Colesevelam can raise the levels of metformin in your body by increasing how much of the drug you are exposed to.
Metformin's labeled portfolio outnumbers Colesevelam
SPL source-record counts only. This page's band is minor · classes on file: Colesevelam (Bile Acid Sequestrant (Diabetes)); Metformin (Biguanide).
0 major · 1 moderate · 14 minor · 15 total
- Other minor peers for Colesevelam
- Warfarin
- Norethindrone
- Cyclosporine
- Glyburide
0 major · 10 moderate · 17 minor · 27 total
- Other minor peers for Metformin
- Topiramate
- Dolutegravir
- Ranolazine
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.