What the FDA labels say about taking them together
Colesevelam and metformin
Colesevelam's FDA label of December 28, 2023 names metformin in its drug interactions section; the metformin labels PlainMeds reads (3) do not name colesevelam. The colesevelam label: “In vivo drug interactions studies showed an increase in metformin extended release (ER) when coadministered with colesevelam hydrochloride.”
Check it at the source: the colesevelam FDA label on DailyMed (effective December 28, 2023, A-S Medication Solutions); the metformin FDA label on DailyMed (effective September 3, 2026, Granules India Ltd).
What does the colesevelam label say about metformin?
Colesevelam label, drug interactionsMetformin Extended Release (ER) Clinical Impact: In vivo drug interactions studies showed an increase in metformin extended release (ER) when coadministered with colesevelam hydrochloride. Intervention: Monitor patients' glycemic control.
Source: FDA drug label (COLESEVELAM HYDROCHLORIDE), NDA021176 (Cosette), as published by A-S Medication Solutions, effective December 28, 2023 (SPL set 0127afae-8d8d-43f2-97f9-4f99f6947e81), via openFDA; the full label on DailyMed
What does the metformin label say about colesevelam?
Metformin's label (effective September 3, 2026) and its 2 other brand-application labels do not name colesevelam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (METFORMIN HYDROCHLORIDE), Granules India Ltd, effective September 3, 2026 (SPL set 73197cb5-3e23-4ac0-b189-f9bc848bce66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Colesevelam | Metformin | |
|---|---|---|
| Labeled for | High cholesterol, Type 2 diabetes | Type 2 diabetes |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.262 per tablet 625 mg tablet | $0.0145 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once