Colesevelam and Norethindrone Interaction
Drug interaction information between Colesevelam and Norethindrone.
Colesevelam and Norethindrone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Colesevelam and Norethindrone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Colesevelam can reduce the amount of birth control medicine that enters your body. This happens because the drug can trap the birth control in your digestive system before it can work.
FDA Label Information
7 DRUG INTERACTIONS Concomitant use with colesevelam hydrochloride may decrease the exposure of the following drugs: Drugs with a narrow therapeutic index (e.g., cyclosporine), phenytoin, thyroid hormone replacement therapy, warfarin, oral contraceptives containing ethinyl estradiol and norethindrone, olmesartan medoxomil, and sulfonylureas (glimepiride, glipizide, glyburide). Oral Contraceptives Containing Ethinyl Estradiol and Norethindrone Clinical Impact: In vivo drug interactions studies showed a decrease in exposure of ethinyl estradiol and norethindrone when coadministered with...
Colesevelam Also Interacts With
- Olmesartan moderate
- Metformin minor
- Warfarin minor
- Cyclosporine minor
- Glyburide minor
Norethindrone Also Interacts With
- Voriconazole major
- Atorvastatin minor
- Colchicine minor
- Darunavir minor
- Fluconazole minor
Frequently Asked Questions
What SPL severity band is on file for Colesevelam + Norethindrone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Colesevelam has 15 labeled pairs on file vs Norethindrone's 10. In the minor band specifically: Colesevelam has 14 (also Metformin, Warfarin, Cyclosporine, Glyburide); Norethindrone has 9 (also Atorvastatin, Colchicine, Darunavir, Fluconazole).
What mechanism field is on file for Colesevelam and Norethindrone?
Colesevelam can reduce the amount of birth control medicine that enters your body. This happens because the drug can trap the birth control in your digestive system before it can work.
Norethindrone carries more major-labeled pairs than Colesevelam
SPL source-record counts only. This page's band is minor · classes on file: Colesevelam (Bile Acid Sequestrant (Diabetes)); Norethindrone (Progestin-Only Oral Contraceptive).
Norethindrone has 1 major-labeled pair vs Colesevelam's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 14 minor · 15 total
- Other minor peers for Colesevelam
- Metformin
- Warfarin
- Cyclosporine
- Glyburide
1 major · 0 moderate · 9 minor · 10 total
- Other minor peers for Norethindrone
- Atorvastatin
- Colchicine
- Darunavir
- Fluconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.