Colesevelam and Cyclosporine Interaction
Drug interaction information between Colesevelam and Cyclosporine.
Colesevelam and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Colesevelam and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Colesevelam can lower the levels of cyclosporine in your body by blocking its absorption. This means there might not be enough medicine in your blood to work correctly.
FDA Label Information
7 DRUG INTERACTIONS Concomitant use with colesevelam hydrochloride may decrease the exposure of the following drugs: Drugs with a narrow therapeutic index (e.g., cyclosporine), phenytoin, thyroid hormone replacement therapy, warfarin, oral contraceptives containing ethinyl estradiol and norethindrone, olmesartan medoxomil, and sulfonylureas (glimepiride, glipizide, glyburide). In vivo drug interactions studies showed a decrease in exposure of cyclosporine when coadministered with colesevelam hydrochloride [see Clinical Pharmacology (12.3) ]. Examples: Cyclosporine Phenytoin Clinical...
Colesevelam Also Interacts With
- Olmesartan moderate
- Metformin minor
- Warfarin minor
- Norethindrone minor
- Glyburide minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Colesevelam + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Colesevelam's 15. In the minor band specifically: Colesevelam has 14 (also Metformin, Warfarin, Norethindrone, Glyburide); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Colesevelam and Cyclosporine?
Colesevelam can lower the levels of cyclosporine in your body by blocking its absorption. This means there might not be enough medicine in your blood to work correctly.
Cyclosporine carries more major-labeled pairs than Colesevelam
SPL source-record counts only. This page's band is minor · classes on file: Colesevelam (Bile Acid Sequestrant (Diabetes)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Colesevelam's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 14 minor · 15 total
- Other minor peers for Colesevelam
- Metformin
- Warfarin
- Norethindrone
- Glyburide
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.